3-N-(4,5-diphenyl-4-oxazolin-2-onyl)-epi-aminonocardicin tert-butyl ester

Base Information

Chemical Name:3-N-(4,5-diphenyl-4-oxazolin-2-onyl)-epi-aminonocardicin tert-butyl ester
CAS No.:1443793-30-3
Molecular Formula:C₃₇H₃₄N₂O₆
Molecular Weight:602.687
Hs Code.:

Synonyms:3-N-(4,5-diphenyl-4-oxazolin-2-onyl)-epi-aminonocardicin tert-butyl ester

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Chemical Property of 3-N-(4,5-diphenyl-4-oxazolin-2-onyl)-epi-aminonocardicin tert-butyl ester

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Technology Process of 3-N-(4,5-diphenyl-4-oxazolin-2-onyl)-epi-aminonocardicin tert-butyl ester

There total 3 articles about 3-N-(4,5-diphenyl-4-oxazolin-2-onyl)-epi-aminonocardicin tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1443793-29-0
N-(4,6-diphenyl-4-oxazolin-2-onyl)-L-seryl-L-[p-(benzyloxy)phenyl]glycine tert-butyl ester

: 1443793-30-3
3-N-(4,5-diphenyl-4-oxazolin-2-onyl)-epi-aminonocardicin tert-butyl ester

Guidance literature:: With diethylazodicarboxylate; triethyl phosphite; In tetrahydrofuran; at 20 ℃; for 12h; Darkness;
DOI:10.1021/jo4007893

Reference yield:

: 336877-72-6
L-2-[p-(benzyloxy)phenyl]glycine

: 1443793-30-3
3-N-(4,5-diphenyl-4-oxazolin-2-onyl)-epi-aminonocardicin tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid / diethyl ether; 1,4-dioxane

2.1: N-ethyl-N,N-diisopropylamine; (benzotriazol-1-yloxy)tripyrrolodinophosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.02 h / 0 °C

2.2: 3 h / 0 - 20 °C

3.1: diethylazodicarboxylate; triethyl phosphite / tetrahydrofuran / 12 h / 20 °C / Darkness

With (benzotriazol-1-yloxy)tripyrrolodinophosphonium hexafluorophosphate; sulfuric acid; N-ethyl-N,N-diisopropylamine; diethylazodicarboxylate; triethyl phosphite; In tetrahydrofuran; 1,4-dioxane; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jo4007893

Reference yield:

: 1443793-28-9
L-[p-(benzyloxy)phenyl]glycine tert-butyl ester toluenesulfonate

: 1443793-30-3
3-N-(4,5-diphenyl-4-oxazolin-2-onyl)-epi-aminonocardicin tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; (benzotriazol-1-yloxy)tripyrrolodinophosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.02 h / 0 °C

1.2: 3 h / 0 - 20 °C

2.1: diethylazodicarboxylate; triethyl phosphite / tetrahydrofuran / 12 h / 20 °C / Darkness

With (benzotriazol-1-yloxy)tripyrrolodinophosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; diethylazodicarboxylate; triethyl phosphite; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo4007893