Technology Process of (6S,7R,8S)-6,7,8-Tris-benzyloxy-5,6,7,8-tetrahydro-imidazo[1,5-a]pyridine
There total 17 articles about (6S,7R,8S)-6,7,8-Tris-benzyloxy-5,6,7,8-tetrahydro-imidazo[1,5-a]pyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 92 percent / NaH, Bu4NI / tetrahydrofuran / Ambient temperature
2: 83 percent / HgO, HgCl2 / acetonitrile / 5 h / Ambient temperature
3: 94 percent / NaBH4 / methanol / Ambient temperature
4: 90 percent / pyridine / Ambient temperature
5: 82 percent / H2O / acetic acid / 8 h / 60 °C
6: 88 percent / NaIO4 / acetone; H2O / Ambient temperature
7: 87 percent / t-BuOK / 1,2-dimethoxy-ethane / 1.5 h / -30 °C
8: 97 percent / POCl3, Et3N / 1,2-dimethoxy-ethane / 1.5 h / -5 °C
9: NH3 / methanol / Ambient temperature
10: 1.) BnSO2Cl, 2.) Ac2O / 1.) Py, -10 deg C, 2 h, 2.) Py, 65 deg C, 1.5 h
With
sodium tetrahydroborate; sodium periodate; potassium tert-butylate; ammonia; water; acetic anhydride; tetra-(n-butyl)ammonium iodide; sodium hydride; triethylamine; mercury dichloride; mercury(II) oxide; trichlorophosphate; benzenesulfonyl chloride;
In
tetrahydrofuran; pyridine; methanol; 1,2-dimethoxyethane; water; acetic acid; acetone; acetonitrile;
DOI:10.1016/S0040-4020(98)00561-4
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 92 percent / NaH, Bu4NI / tetrahydrofuran / Ambient temperature
2: 83 percent / HgO, HgCl2 / acetonitrile / 5 h / Ambient temperature
3: 94 percent / NaBH4 / methanol / Ambient temperature
4: 90 percent / pyridine / Ambient temperature
5: 82 percent / H2O / acetic acid / 8 h / 60 °C
6: 88 percent / NaIO4 / acetone; H2O / Ambient temperature
7: 87 percent / t-BuOK / 1,2-dimethoxy-ethane / 1.5 h / -30 °C
8: 97 percent / POCl3, Et3N / 1,2-dimethoxy-ethane / 1.5 h / -5 °C
9: NH3 / methanol / Ambient temperature
10: 1.) BnSO2Cl, 2.) Ac2O / 1.) Py, -10 deg C, 2 h, 2.) Py, 65 deg C, 1.5 h
With
sodium tetrahydroborate; sodium periodate; potassium tert-butylate; ammonia; water; acetic anhydride; tetra-(n-butyl)ammonium iodide; sodium hydride; triethylamine; mercury dichloride; mercury(II) oxide; trichlorophosphate; benzenesulfonyl chloride;
In
tetrahydrofuran; pyridine; methanol; 1,2-dimethoxyethane; water; acetic acid; acetone; acetonitrile;
DOI:10.1016/S0040-4020(98)00561-4
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 90 percent / pyridine / Ambient temperature
2: 82 percent / H2O / acetic acid / 8 h / 60 °C
3: 88 percent / NaIO4 / acetone; H2O / Ambient temperature
4: 87 percent / t-BuOK / 1,2-dimethoxy-ethane / 1.5 h / -30 °C
5: 97 percent / POCl3, Et3N / 1,2-dimethoxy-ethane / 1.5 h / -5 °C
6: NH3 / methanol / Ambient temperature
7: 1.) BnSO2Cl, 2.) Ac2O / 1.) Py, -10 deg C, 2 h, 2.) Py, 65 deg C, 1.5 h
With
sodium periodate; potassium tert-butylate; ammonia; water; acetic anhydride; triethylamine; trichlorophosphate; benzenesulfonyl chloride;
In
pyridine; methanol; 1,2-dimethoxyethane; water; acetic acid; acetone;
DOI:10.1016/S0040-4020(98)00561-4
