3-(Benzyloxycarbonyl-{3-[benzyloxycarbonyl-(3-benzyloxycarbonylamino-propyl)-amino]-propyl}-amino)-propionic acid ethyl ester

Base Information

• Chemical Name: 3-(Benzyloxycarbonyl-{3-[benzyloxycarbonyl-(3-benzyloxycarbonylamino-propyl)-amino]-propyl}-amino)-propionic acid ethyl ester
• CAS No.: 121903-82-0
• Molecular Formula: C₃₅H₄₃N₃O₈
• Molecular Weight: 633.742
• Mol file: 121903-82-0.mol

Synonyms:

Chemical Property of 3-(Benzyloxycarbonyl-{3-[benzyloxycarbonyl-(3-benzyloxycarbonylamino-propyl)-amino]-propyl}-amino)-propionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(Benzyloxycarbonyl-{3-[benzyloxycarbonyl-(3-benzyloxycarbonylamino-propyl)-amino]-propyl}-amino)-propionic acid ethyl ester

There total 1 articles about 3-(Benzyloxycarbonyl-{3-[benzyloxycarbonyl-(3-benzyloxycarbonylamino-propyl)-amino]-propyl}-amino)-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

ethyl 4,8,12-triazadodecanoate (79405-62-2) + benzyl chloroformate (501-53-1,94274-21-2) → 3-(Benzyloxycarbonyl-{3-[benzyloxycarbonyl-(3-benzyloxycarbonylamino-propyl)-amino]-propyl}-amino)-propionic acid ethyl ester (121903-82-0)

Guidance literature:

With sodium hydrogencarbonate; In diethyl ether; water;

DOI:10.1016/S0040-4039(00)96340-8

Reference yield:

3-(Benzyloxycarbonyl-{3-[benzyloxycarbonyl-(3-benzyloxycarbonylamino-propyl)-amino]-propyl}-amino)-propionic acid ethyl ester (121903-82-0) → (S)-N1-(5-{3-[3-(3-Amino-propylamino)-propylamino]-propionylamino}-pentyl)-2-[2-(2,4-dihydroxy-phenyl)-acetylamino]-succinamide; hydrochloride (113954-19-1)

Guidance literature:

Multi-step reaction with 3 steps

1: KOH / ethanol / Ambient temperature

2: 70 percent / DCC / dimethylformamide

3: 2) H₂ / 1) 1-hydroxybenzotriazole; 2) 10percent Pd-C / 1) DMF, room temp.; 2) CH₃COOH, room temp., 2 h

With potassium hydroxide; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; benzotriazol-1-ol; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)96340-8

Reference yield:

3-(Benzyloxycarbonyl-{3-[benzyloxycarbonyl-(3-benzyloxycarbonylamino-propyl)-amino]-propyl}-amino)-propionic acid ethyl ester (121903-82-0) → 3-(Benzyloxycarbonyl-{3-[benzyloxycarbonyl-(3-benzyloxycarbonylamino-propyl)-amino]-propyl}-amino)-propionic acid (121903-83-1)

Guidance literature:

With potassium hydroxide; In ethanol; Yield given; Ambient temperature;

DOI:10.1016/S0040-4039(00)96340-8

upstream raw materials:

ethyl 4,8,12-triazadodecanoate

benzyl chloroformate

Downstream raw materials:

3-(Benzyloxycarbonyl-{3-[benzyloxycarbonyl-(3-benzyloxycarbonylamino-propyl)-amino]-propyl}-amino)-propionic acid

3-(Benzyloxycarbonyl-{3-[benzyloxycarbonyl-(3-benzyloxycarbonylamino-propyl)-amino]-propyl}-amino)-propionic acid 4-nitro-phenyl ester

(S)-N¹-(5-{3-[3-(3-Amino-propylamino)-propylamino]-propionylamino}-pentyl)-2-[2-(2,4-dihydroxy-phenyl)-acetylamino]-succinamide; hydrochloride