2-Oxa-4,8,12-triazapentadecan-15-oic acid, 3-oxo-1-phenyl-8,12-bis[(phenylmethoxy)carbonyl]-, 4-nitrophenyl ester

Base Information

• Chemical Name: 2-Oxa-4,8,12-triazapentadecan-15-oic acid, 3-oxo-1-phenyl-8,12-bis[(phenylmethoxy)carbonyl]-, 4-nitrophenyl ester
• CAS No.: 113954-17-9
• Molecular Formula: C39H42N4O10
• Molecular Weight: 726.783
• Mol file: 113954-17-9.mol

Synonyms:

Chemical Property of 2-Oxa-4,8,12-triazapentadecan-15-oic acid, 3-oxo-1-phenyl-8,12-bis[(phenylmethoxy)carbonyl]-, 4-nitrophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Oxa-4,8,12-triazapentadecan-15-oic acid, 3-oxo-1-phenyl-8,12-bis[(phenylmethoxy)carbonyl]-, 4-nitrophenyl ester

There total 4 articles about 2-Oxa-4,8,12-triazapentadecan-15-oic acid, 3-oxo-1-phenyl-8,12-bis[(phenylmethoxy)carbonyl]-, 4-nitrophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + 3-(Benzyloxycarbonyl-{3-[benzyloxycarbonyl-(3-benzyloxycarbonylamino-propyl)-amino]-propyl}-amino)-propionic acid (121903-83-1) → 3-(Benzyloxycarbonyl-{3-[benzyloxycarbonyl-(3-benzyloxycarbonylamino-propyl)-amino]-propyl}-amino)-propionic acid 4-nitro-phenyl ester (113954-17-9)

Guidance literature:

With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)96340-8

Reference yield:

ethyl 4,8,12-triazadodecanoate (79405-62-2) → 3-(Benzyloxycarbonyl-{3-[benzyloxycarbonyl-(3-benzyloxycarbonylamino-propyl)-amino]-propyl}-amino)-propionic acid 4-nitro-phenyl ester (113954-17-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 40 percent / NaHCO₃ / diethyl ether; H₂O

2: KOH / ethanol / Ambient temperature

3: 70 percent / DCC / dimethylformamide

With potassium hydroxide; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In diethyl ether; ethanol; water; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)96340-8

Reference yield:

3-(Benzyloxycarbonyl-{3-[benzyloxycarbonyl-(3-benzyloxycarbonylamino-propyl)-amino]-propyl}-amino)-propionic acid ethyl ester (121903-82-0) → 3-(Benzyloxycarbonyl-{3-[benzyloxycarbonyl-(3-benzyloxycarbonylamino-propyl)-amino]-propyl}-amino)-propionic acid 4-nitro-phenyl ester (113954-17-9)

Guidance literature:

Multi-step reaction with 2 steps

1: KOH / ethanol / Ambient temperature

2: 70 percent / DCC / dimethylformamide

With potassium hydroxide; dicyclohexyl-carbodiimide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)96340-8

upstream raw materials:

4-nitro-phenol

3-(Benzyloxycarbonyl-{3-[benzyloxycarbonyl-(3-benzyloxycarbonylamino-propyl)-amino]-propyl}-amino)-propionic acid

ethyl 4,8,12-triazadodecanoate

3-(Benzyloxycarbonyl-{3-[benzyloxycarbonyl-(3-benzyloxycarbonylamino-propyl)-amino]-propyl}-amino)-propionic acid ethyl ester

Downstream raw materials:

(S)-N¹-(5-{3-[3-(3-Amino-propylamino)-propylamino]-propionylamino}-pentyl)-2-[2-(2,4-dihydroxy-phenyl)-acetylamino]-succinamide; hydrochloride