Technology Process of (2E,4E)-1--5-(4'-chlorophenyl)-2,4-pentadiene
There total 5 articles about (2E,4E)-1--5-(4'-chlorophenyl)-2,4-pentadiene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tert-butyl (E)-4-(1-phenyl-1H-tetrazol-5-ylsulfonyl)but-2-enyl carbamate;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran;
at -78 ℃;
4-chlorobenzaldehyde;
In
tetrahydrofuran;
at -78 - 20 ℃;
optical yield given as %de;
DOI:10.1055/s-2008-1078011
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) NaH / 1.) DMF, 0 deg C, 2a.) 10 min, 2b.) 60-65 deg C, 3 h
2: CF3COOH / CH2Cl2 / 3.5 h / 20 - 22 °C
3: 83 percent / NaI / 20 h / 90 - 100 °C
4: 1.) sodium bis(trimethylsilyl)amide / 1.) THF, -78 deg C, 10 min, 2a.) 15 min, 2b.) from -78 deg C to -10 deg C, 5 h, 2c.) 30 min
With
sodium hexamethyldisilazane; sodium hydride; trifluoroacetic acid; sodium iodide;
In
dichloromethane;
DOI:10.1021/jo00275a021
- Guidance literature:
-
Multi-step reaction with 3 steps
1: CF3COOH / CH2Cl2 / 3.5 h / 20 - 22 °C
2: 83 percent / NaI / 20 h / 90 - 100 °C
3: 1.) sodium bis(trimethylsilyl)amide / 1.) THF, -78 deg C, 10 min, 2a.) 15 min, 2b.) from -78 deg C to -10 deg C, 5 h, 2c.) 30 min
With
sodium hexamethyldisilazane; trifluoroacetic acid; sodium iodide;
In
dichloromethane;
DOI:10.1021/jo00275a021
