N-<3-(4-morpholinyl)propyl>-(2S,4'S,5'S)-2-<<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4-(cyclohexylmethyl)-5-oxazolidinyl>methyl>-3-methylbutanamide

Base Information

Chemical Name:N-<3-(4-morpholinyl)propyl>-(2S,4'S,5'S)-2-<<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4-(cyclohexylmethyl)-5-oxazolidinyl>methyl>-3-methylbutanamide
CAS No.:130316-92-6
Molecular Formula:C₃₀H₅₅N₃O₅
Molecular Weight:537.784
Hs Code.:

N-<3-(4-morpholinyl)propyl>-(2S,4'S,5'S)-2-<<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4-(cyclohexylmethyl)-5-oxazolidinyl>methyl>-3-methylbutanamide

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Chemical Property of N-<3-(4-morpholinyl)propyl>-(2S,4'S,5'S)-2-<<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4-(cyclohexylmethyl)-5-oxazolidinyl>methyl>-3-methylbutanamide

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Technology Process of N-<3-(4-morpholinyl)propyl>-(2S,4'S,5'S)-2-<<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4-(cyclohexylmethyl)-5-oxazolidinyl>methyl>-3-methylbutanamide

There total 2 articles about N-<3-(4-morpholinyl)propyl>-(2S,4'S,5'S)-2-<<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4-(cyclohexylmethyl)-5-oxazolidinyl>methyl>-3-methylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 130316-92-6
N-<3-(4-morpholinyl)propyl>-(2S,4'S,5'S)-2-<<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4-(cyclohexylmethyl)-5-oxazolidinyl>methyl>-3-methylbutanamide

Guidance literature:

Reference yield:

: 123-00-2
4-(3-Aminopropyl)morpholine

: 129921-93-3
2-(S)-((3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-(cyclohexylmethyl)-5(S)-oxazolidinyl)methyl)-3-methylbutanoic acid

: 130316-92-6
N-<3-(4-morpholinyl)propyl>-(2S,4'S,5'S)-2-<<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4-(cyclohexylmethyl)-5-oxazolidinyl>methyl>-3-methylbutanamide

Guidance literature:: With 4-methyl-morpholine; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; Yield given. Multistep reaction; 1 a.) DMF, from -20 deg C to 0 deg C, 1 h, b.) 0 deg C, 24 h, 2 a.) DMF, 0 deg C, 4 h, b.) from 0 deg C to RT, 20 h;
DOI:10.1021/jm00088a007

Reference yield:

: 130316-92-6
N-<3-(4-morpholinyl)propyl>-(2S,4'S,5'S)-2-<<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4-(cyclohexylmethyl)-5-oxazolidinyl>methyl>-3-methylbutanamide

: 138679-12-6
(2S,4S,5S)-5-Amino-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid (3-morpholin-4-yl-propyl)-amide

Guidance literature:: With trifluoroacetic acid; Multistep reaction; 1.) CH₂Cl₂, from -10 deg C to 0 deg C, 4 h,2.) THF, water, RT, 18 h;
DOI:10.1021/jm00088a007