4-[5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-10-formyl-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-1,4,5,10-tetrahydrodipyrrin

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Chemical Name:4-[5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-10-formyl-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-1,4,5,10-tetrahydrodipyrrin
CAS No.:208238-41-9
Molecular Formula:C₄₄H₅₃N₃O₁₅
Molecular Weight:863.916
Hs Code.:

4-[5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-10-formyl-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-1,4,5,10-tetrahydrodipyrrin

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Chemical Property of 4-[5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-10-formyl-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-1,4,5,10-tetrahydrodipyrrin

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Technology Process of 4-[5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-10-formyl-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-1,4,5,10-tetrahydrodipyrrin

There total 8 articles about 4-[5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-10-formyl-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-1,4,5,10-tetrahydrodipyrrin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 107-31-3
Methyl formate

: 208238-33-9
4-[5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-1,4,5,10-tetrahydrodipyrrin

: 208238-41-9
4-[5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-10-formyl-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-1,4,5,10-tetrahydrodipyrrin

Guidance literature:: With 2-Pyridone; N,N-dimethyl-formamide; at 100 ℃; for 40h;

Reference yield:

: 155435-04-4
C₄₄H₅₁N₃O₁₇

: 208238-41-9
4-[5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-10-formyl-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-1,4,5,10-tetrahydrodipyrrin

Guidance literature:: Multi-step reaction with 7 steps

1: DCC, DMAP / CH₂Cl₂ / 3 h / Ambient temperature

2: 71 percent / p-tolyl Davy's reagent / 1,2-dimethoxy-ethane / 0.17 h / Heating

3: 78 percent / AcOH, nickel boride, H₂ / methanol / 2 h

4: 80 percent / NaBH₄ / methanol / 0.08 h / Ambient temperature

5: TBAF / tetrahydrofuran / 3 h / Ambient temperature

6: 3 h / Ambient temperature

7: 75 percent / 2-pyridone, DMF / 40 h / 100 °C

With 2-Pyridone; dmap; sodium tetrahydroborate; nickel boride; tetrabutyl ammonium fluoride; hydrogen; acetic acid; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide; 2,4-bis(4-methylphenylthio)-1,3,2λ⁵,4λ⁵-dithiadiphosphetane-2,4-dithione; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane;

Reference yield:

: 155435-03-3
4-[5-benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-9-(2,2,2-tribromoethoxycarbonyl)-4,5-dihydrodipyrrin-1(10H)-one

: 208238-41-9
4-[5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-10-formyl-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-1,4,5,10-tetrahydrodipyrrin

Guidance literature:: Multi-step reaction with 8 steps

1: Zn, glacial acetic acid / 0.5 h / Ambient temperature

2: DCC, DMAP / CH₂Cl₂ / 3 h / Ambient temperature

3: 71 percent / p-tolyl Davy's reagent / 1,2-dimethoxy-ethane / 0.17 h / Heating

4: 78 percent / AcOH, nickel boride, H₂ / methanol / 2 h

5: 80 percent / NaBH₄ / methanol / 0.08 h / Ambient temperature

6: TBAF / tetrahydrofuran / 3 h / Ambient temperature

7: 3 h / Ambient temperature

8: 75 percent / 2-pyridone, DMF / 40 h / 100 °C

With 2-Pyridone; dmap; sodium tetrahydroborate; nickel boride; tetrabutyl ammonium fluoride; hydrogen; acetic acid; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide; 2,4-bis(4-methylphenylthio)-1,3,2λ⁵,4λ⁵-dithiadiphosphetane-2,4-dithione; zinc; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane;