1-[(2-chloro-5-thiazolyl)methyl]-3-[2'-chloro-4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]-2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidinium inner salt

Base Information

• Chemical Name: 1-[(2-chloro-5-thiazolyl)methyl]-3-[2'-chloro-4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]-2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidinium inner salt
• CAS No.: 1263137-20-7
• Molecular Formula: C₂₅H₁₄Cl₂F₃N₃O₂S
• Molecular Weight: 548.372
• Mol file: 1263137-20-7.mol

Synonyms:

Chemical Property of 1-[(2-chloro-5-thiazolyl)methyl]-3-[2'-chloro-4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]-2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidinium inner salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[(2-chloro-5-thiazolyl)methyl]-3-[2'-chloro-4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]-2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidinium inner salt

There total 9 articles about 1-[(2-chloro-5-thiazolyl)methyl]-3-[2'-chloro-4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]-2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidinium inner salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[(2-chloro-1,3-thiazol-5-yl)methyl]pyridin-2-amine (1176959-68-4) + 1,3-bis(2,4,6-trichlorophenyl) 2-[2'-chloro-4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]propanedioate (1263140-38-0) → 1-[(2-chloro-5-thiazolyl)methyl]-3-[2'-chloro-4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]-2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidinium inner salt (1263137-20-7)

Guidance literature:

at 80 ℃; for 3h;

Reference yield:

1-Bromo-3-iodobenzene (591-18-4) → 1-[(2-chloro-5-thiazolyl)methyl]-3-[2'-chloro-4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]-2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidinium inner salt (1263137-20-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: caesium carbonate / copper(l) iodide; 2-Picolinic acid / 1,4-dioxane / 50 °C

1.2: 20 - 25 °C

2.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 0.5 h / 80 °C

3.1: sodium hydroxide; water / 0.33 h / 50 °C

3.2: 10 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1.5 h / Inert atmosphere

5.1: dichloromethane

6.1: 3 h / 80 °C

With oxalyl dichloride; water; sodium carbonate; caesium carbonate; sodium hydroxide; 2-Picolinic acid; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; water;

Reference yield:

diethyl (3-bromophenyl)malonate (56911-48-9) → 1-[(2-chloro-5-thiazolyl)methyl]-3-[2'-chloro-4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]-2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidinium inner salt (1263137-20-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 0.5 h / 80 °C

2.1: sodium hydroxide; water / 0.33 h / 50 °C

2.2: 10 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1.5 h / Inert atmosphere

4.1: dichloromethane

5.1: 3 h / 80 °C

With oxalyl dichloride; water; sodium carbonate; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; water;

upstream raw materials:

1-Bromo-3-iodobenzene

diethyl (3-bromophenyl)malonate

3-iodophenylacetic acid ethyl ester

N-[(2-chloro-1,3-thiazol-5-yl)methyl]pyridin-2-amine