1-[(2-chloro-5-thiazolyl)methyl]-3-[2'-chloro-4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]-2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidinium inner salt

Base Information

Chemical Name:1-[(2-chloro-5-thiazolyl)methyl]-3-[2'-chloro-4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]-2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidinium inner salt
CAS No.:1263137-20-7
Molecular Formula:C₂₅H₁₄Cl₂F₃N₃O₂S
Molecular Weight:548.372
Hs Code.:

1-[(2-chloro-5-thiazolyl)methyl]-3-[2'-chloro-4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]-2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidinium inner salt

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Chemical Property of 1-[(2-chloro-5-thiazolyl)methyl]-3-[2'-chloro-4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]-2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidinium inner salt

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Technology Process of 1-[(2-chloro-5-thiazolyl)methyl]-3-[2'-chloro-4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]-2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidinium inner salt

There total 9 articles about 1-[(2-chloro-5-thiazolyl)methyl]-3-[2'-chloro-4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]-2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidinium inner salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1176959-68-4
N-[(2-chloro-1,3-thiazol-5-yl)methyl]pyridin-2-amine

: 1263140-38-0
1,3-bis(2,4,6-trichlorophenyl) 2-[2'-chloro-4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]propanedioate

: 1263137-20-7
1-[(2-chloro-5-thiazolyl)methyl]-3-[2'-chloro-4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]-2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidinium inner salt

Guidance literature:: at 80 ℃; for 3h;

Reference yield:

: 591-18-4
1-Bromo-3-iodobenzene

: 1263137-20-7
1-[(2-chloro-5-thiazolyl)methyl]-3-[2'-chloro-4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]-2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidinium inner salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / copper(l) iodide; 2-Picolinic acid / 1,4-dioxane / 50 °C

1.2: 20 - 25 °C

2.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 0.5 h / 80 °C

3.1: sodium hydroxide; water / 0.33 h / 50 °C

3.2: 10 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1.5 h / Inert atmosphere

5.1: dichloromethane

6.1: 3 h / 80 °C

With oxalyl dichloride; water; sodium carbonate; caesium carbonate; sodium hydroxide; 2-Picolinic acid; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; water;

Reference yield:

: 56911-48-9
diethyl (3-bromophenyl)malonate

: 1263137-20-7
1-[(2-chloro-5-thiazolyl)methyl]-3-[2'-chloro-4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]-2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidinium inner salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 0.5 h / 80 °C

2.1: sodium hydroxide; water / 0.33 h / 50 °C

2.2: 10 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1.5 h / Inert atmosphere

4.1: dichloromethane

5.1: 3 h / 80 °C

With oxalyl dichloride; water; sodium carbonate; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; water;