N-<(2R)-7-ethoxycarbonylmethoxy-1,2,3,4-tetrahydronaphth-2-yl>-(2R)-2-(3-chlorophenyl)-2-hydroxyethanamine

Base Information

• Chemical Name: N-<(2R)-7-ethoxycarbonylmethoxy-1,2,3,4-tetrahydronaphth-2-yl>-(2R)-2-(3-chlorophenyl)-2-hydroxyethanamine
• CAS No.: 121524-07-0
• Molecular Formula: C₂₂H₂₆ClNO₄
• Molecular Weight: 403.906
• Mol file: 121524-07-0.mol

Synonyms:

Chemical Property of N-<(2R)-7-ethoxycarbonylmethoxy-1,2,3,4-tetrahydronaphth-2-yl>-(2R)-2-(3-chlorophenyl)-2-hydroxyethanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<(2R)-7-ethoxycarbonylmethoxy-1,2,3,4-tetrahydronaphth-2-yl>-(2R)-2-(3-chlorophenyl)-2-hydroxyethanamine

There total 10 articles about N-<(2R)-7-ethoxycarbonylmethoxy-1,2,3,4-tetrahydronaphth-2-yl>-(2R)-2-(3-chlorophenyl)-2-hydroxyethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-7-methoxy-1,2,3,4-tetrahydronaphthalene (4003-89-8,118298-16-1) → N-<(2R)-7-ethoxycarbonylmethoxy-1,2,3,4-tetrahydronaphth-2-yl>-(2R)-2-(3-chlorophenyl)-2-hydroxyethanamine (121524-07-0)

Guidance literature:

Multi-step reaction with 6 steps

2: 30 percent / 1.) 48percent HBr aq., 2.) NH₄OH / 3 h / Heating

3: 96 percent / TEA / dimethylformamide / 3 h / Ambient temperature

4: 72 percent / K₂CO₃ / acetone / 6 h / Heating

5: TFA / CH₂Cl₂ / 4 h / Ambient temperature

6: dimethylsulfoxide / 80 °C

With ammonium hydroxide; TEA; hydrogen bromide; potassium carbonate; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;

DOI:10.1016/0223-5234(94)90095-7

Reference yield:

(+)-7-OH-AT (85951-61-7) → N-<(2R)-7-ethoxycarbonylmethoxy-1,2,3,4-tetrahydronaphth-2-yl>-(2R)-2-(3-chlorophenyl)-2-hydroxyethanamine (121524-07-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 96 percent / TEA / dimethylformamide / 3 h / Ambient temperature

2: 72 percent / K₂CO₃ / acetone / 6 h / Heating

3: TFA / CH₂Cl₂ / 4 h / Ambient temperature

4: dimethylsulfoxide / 80 °C

With TEA; potassium carbonate; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;

DOI:10.1016/0223-5234(94)90095-7

Reference yield:

(2R)-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine (121216-43-1,118298-16-1) → N-<(2R)-7-ethoxycarbonylmethoxy-1,2,3,4-tetrahydronaphth-2-yl>-(2R)-2-(3-chlorophenyl)-2-hydroxyethanamine (121524-07-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 30 percent / 1.) 48percent HBr aq., 2.) NH₄OH / 3 h / Heating

2: 96 percent / TEA / dimethylformamide / 3 h / Ambient temperature

3: 72 percent / K₂CO₃ / acetone / 6 h / Heating

4: TFA / CH₂Cl₂ / 4 h / Ambient temperature

5: dimethylsulfoxide / 80 °C

With ammonium hydroxide; TEA; hydrogen bromide; potassium carbonate; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;

DOI:10.1016/0223-5234(94)90095-7

upstream raw materials:

(R)-meta-chlorostyrene oxide

(R)-(+)-2-amino-7-ethoxycarbonylmethoxytetralin

2-amino-7-methoxy-1,2,3,4-tetrahydronaphthalene

(+)-7-OH-AT