GDC-0339

Base Information

• Chemical Name: GDC-0339
• CAS No.: 1428569-85-0
• Molecular Formula: C₂₀H₂₂F₃N₇OS
• Molecular Weight: 465.502
• Mol file: 1428569-85-0.mol

Synonyms:

Chemical Property of GDC-0339

Chemical Property:

• PKA: 9.28±0.40(Predicted)
• Density: 1.61±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

GDC-0339 99.96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of GDC-0339

There total 13 articles about GDC-0339 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

rac-(4R,5R)-5-azido-1-(1-methyl-4-nitro-1H-pyrazol-5-yl)azepan-4-ol → 5-amino-N-(5-((4R,5R)-4-amino-5-fluoroazepan-1-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide (1428569-85-0)

Guidance literature:

Multi-step reaction with 7 steps

1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / tetrahydrofuran; dichloromethane / 20.33 h / 20 °C / Cooling with ice

2: triphenylphosphine / tetrahydrofuran; water / 20 h / 60 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C / Cooling with ice

4: Chiralpak IA column / Resolution of racemate

5: ammonium chloride; iron / water; ethanol / 2.75 h / 99 °C

6: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 48 h / 20 °C

7: hydrogenchloride / methanol; 1,4-dioxane / 20 h / 20 °C

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water;

DOI:10.1038/nature24006

Reference yield:

(Z)-2,3,6,7-tetrahydro-1H-azepine hydrochloride (1263282-12-7) → 5-amino-N-(5-((4R,5R)-4-amino-5-fluoroazepan-1-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide (1428569-85-0)

Guidance literature:

Multi-step reaction with 10 steps

1: N-ethyl-N,N-diisopropylamine; potassium fluoride / dimethyl sulfoxide / 21 h / 75 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 20 °C / Cooling with ice

3: ammonium chloride; sodium azide / methanol; water / 22 h / 70 °C

4: (bis-(2-methoxyethyl)amino)sulfur trufluoride / tetrahydrofuran; dichloromethane / 20.33 h / 20 °C / Cooling with ice

5: triphenylphosphine / tetrahydrofuran; water / 20 h / 60 °C

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C / Cooling with ice

7: Chiralpak IA column / Resolution of racemate

8: ammonium chloride; iron / water; ethanol / 2.75 h / 99 °C

9: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 48 h / 20 °C

10: hydrogenchloride / methanol; 1,4-dioxane / 20 h / 20 °C

With hydrogenchloride; potassium fluoride; sodium azide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide;

DOI:10.1038/nature24006

Reference yield:

(Z)-1-(1-methyl-4-nitro-1H-pyrazol-5-yl)-2,3,6,7-tetrahydro-1H-azepine → 5-amino-N-(5-((4R,5R)-4-amino-5-fluoroazepan-1-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide (1428569-85-0)

Guidance literature:

Multi-step reaction with 9 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 20 °C / Cooling with ice

2: ammonium chloride; sodium azide / methanol; water / 22 h / 70 °C

3: (bis-(2-methoxyethyl)amino)sulfur trufluoride / tetrahydrofuran; dichloromethane / 20.33 h / 20 °C / Cooling with ice

4: triphenylphosphine / tetrahydrofuran; water / 20 h / 60 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C / Cooling with ice

6: Chiralpak IA column / Resolution of racemate

7: ammonium chloride; iron / water; ethanol / 2.75 h / 99 °C

8: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 48 h / 20 °C

9: hydrogenchloride / methanol; 1,4-dioxane / 20 h / 20 °C

With hydrogenchloride; sodium azide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water;

DOI:10.1038/nature24006

upstream raw materials:

(Z)-2,3,6,7-tetrahydro-1H-azepine hydrochloride

5-[(tert-butoxycarbonyl)amino]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxylic acid

(Z)-2,3,6,7-tetrahydroazepine-1-carboxylic acid tert-butyl ester

di(but-3-en-1-yl)amine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1428569-85-0 GDC-0339

Send

Send

Metric Ton KG G Pound L ML

Send

Send