2-Hydroxy-1-(4-methyl-2-phenyl-5-thiazolyl)ethanone

Base Information

Chemical Name:2-Hydroxy-1-(4-methyl-2-phenyl-5-thiazolyl)ethanone
CAS No.:122229-25-8
Molecular Formula:C₁₂H₁₁NO₂S
Molecular Weight:233.291
Hs Code.:
DSSTox Substance ID:DTXSID901222412

Synonyms:2-Hydroxy-1-(4-methyl-2-phenyl-5-thiazolyl)ethanone;DTXSID901222412;122229-25-8

Suppliers and Price of 2-Hydroxy-1-(4-methyl-2-phenyl-5-thiazolyl)ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Hydroxy-1-(4-methyl-2-phenyl-5-thiazolyl)ethanone

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:233.05104977
Heavy Atom Count:16
Complexity:253

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(SC(=N1)C2=CC=CC=C2)C(=O)CO

Technology Process of 2-Hydroxy-1-(4-methyl-2-phenyl-5-thiazolyl)ethanone

There total 3 articles about 2-Hydroxy-1-(4-methyl-2-phenyl-5-thiazolyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 122229-20-3
2,2-Dimethoxy-2-(4-methyl-2-phenyl-thiazol-5-yl)-ethanol

: 122229-25-8
2-hydroxy-1-(4-methyl-2-phenyl-thiazol-5-yl)-ethanone

Guidance literature:: With hydrogenchloride; for 14h; Ambient temperature;

Reference yield:

: 7520-94-7
5-acetyl-4-methyl-2-phenylthiazole

: 122229-25-8
2-hydroxy-1-(4-methyl-2-phenyl-thiazol-5-yl)-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 1) potassium hydroxide, 2) iodobenzene diacetate / 1) 0-5 deg C, 5 min, 2) a) 0-5 deg C, 2 h, b) RT, overnight

2: 78 percent / 6 N HCl / 14 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; [bis(acetoxy)iodo]benzene;