C₁₇H₁₆BrNO₂S

Base Information

• Chemical Name: C₁₇H₁₆BrNO₂S
• CAS No.: 1448544-29-3
• Molecular Formula: C₁₇H₁₆BrNO₂S
• Molecular Weight: 378.29
• Mol file: 1448544-29-3.mol

Synonyms:

Chemical Property of C₁₇H₁₆BrNO₂S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₇H₁₆BrNO₂S

There total 3 articles about C₁₇H₁₆BrNO₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(+)-(R)-2-cyclopropylindoline (1448544-25-9) + 4-bromobenzenesulfonyl chloride (98-58-8) → C17H16BrNO2S (1448544-29-3)

Guidance literature:

With pyridine; at 20 ℃; for 24h;

DOI:10.1021/ja406004q

Reference yield:

(±)-2-cyclopropylindoline → C17H16BrNO2S (1448544-29-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N-(1-phenyl-ethylidene)-(3,4,5-trimethoxy-phenyl)-amine; (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid / benzene / 20 h / 20 - 50 °C / Molecular sieve; Inert atmosphere

2: pyridine / 24 h / 20 °C

With pyridine; (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid; N-(1-phenyl-ethylidene)-(3,4,5-trimethoxy-phenyl)-amine; In benzene;

DOI:10.1021/ja406004q

Reference yield:

2-cyclopropyl-1H-indole (40748-44-5) → C17H16BrNO2S (1448544-29-3)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium cyanoborohydride; acetic acid / 12 h / 20 °C

2: N-(1-phenyl-ethylidene)-(3,4,5-trimethoxy-phenyl)-amine; (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid / benzene / 20 h / 20 - 50 °C / Molecular sieve; Inert atmosphere

3: pyridine / 24 h / 20 °C

With pyridine; (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid; N-(1-phenyl-ethylidene)-(3,4,5-trimethoxy-phenyl)-amine; sodium cyanoborohydride; acetic acid; In benzene;

DOI:10.1021/ja406004q

upstream raw materials:

(+)-(R)-2-cyclopropylindoline

4-bromobenzenesulfonyl chloride

2-cyclopropyl-1H-indole