40748-44-5

Basic information

• Product Name: 1H-Indole, 2-cyclopropyl-
• CAS NO: 40748-44-5
• Molecular Formula: C11H11N
• Molecular Weight: 157.215
• Mol File: 40748-44-5.mol

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 2-cyclopropyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 2-cyclopropyl-(40748-44-5)
• EPA Substance Registry System: 1H-Indole, 2-cyclopropyl-(40748-44-5)

Safety Data

• Hazardous Substances Data: 40748-44-5(Hazardous Substances Data)

Usage

General Description

1H-Indole, 2-cyclopropyl- is a chemical compound with the molecular formula C11H9N. It is an indole derivative with a cyclopropyl group attached to the 2-position of the indole ring. 1H-Indole, 2-cyclopropyl- is a heterocyclic aromatic compound and is commonly used as a building block in organic synthesis. It is known for its diverse biological activities and is often utilized in the pharmaceutical industry for the development of new drugs. Its unique structure and reactivity make it an important intermediate in the production of various pharmaceutical and agrochemical products. Additionally, it also serves as a valuable tool in the field of organic chemistry for the preparation of complex molecules.

Upstream product

• 6746-94-7 Cyclopropylacetylene 
• 143321-89-5 2,2,2-trifluoro-N-(2-iodophenyl)acetamide 
• 835893-46-4 2-(2-cyclopropylethyl)phenyl azide 

Downstream Products

• 1448544-29-3 C₁₇H₁₆BrNO₂S 
• 934840-25-2 2-cyclopropyl-1-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]-1H-indole 
• 329015-23-8 2,5-dichloro-3-(2-cyclopropyl-1H-indol-3-yl)[1,4]benzoquinone 

Relevant articles and documents

Iron-Catalyzed Intramolecular Aminations of C(sp3)?H Bonds in Alkylaryl Azides

The nucleophilic iron complex Bu4N[Fe(CO)3(NO)] (TBA[Fe]) catalyzes the direct intramolecular amination of unactivated C(sp3)?H bonds in alkylaryl azides, which results in the formation of substituted indoline and tetrahydroquinoline derivatives.

Palladium-free copper-catalyzed Sonogashira cross-coupling at room temperature

We have developed an efficient method for the palladium-free copper-catalyzed Sonogashira cross-coupling of o-iodoacetanilide derivatives with alkynes at room temperature; the corresponding coupling products were obtained in good to excellent yields using copper(I) iodide/N-methylpyrrolidine- 2-carboxamide as the catalyst. This inexpensive catalyst system has high tolerance towards various functional groups in the substrates. This represents the lowest reaction temperatures for copper-catalyzed Sonogashira cross-coupling thus far. Georg Thieme Verlag Stuttgart.