methyl 4-[2-[[2-(2,4-difluorophenoxy)-2-[4-(1-piperidylsulfonyl)phenyl]acetyl]amino]thiazol-5-yl]oxybenzoate

Base Information

Chemical Name:methyl 4-[2-[[2-(2,4-difluorophenoxy)-2-[4-(1-piperidylsulfonyl)phenyl]acetyl]amino]thiazol-5-yl]oxybenzoate
CAS No.:1328984-50-4
Molecular Formula:C₃₀H₂₇F₂N₃O₇S₂
Molecular Weight:643.689
Hs Code.:

Synonyms:

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Chemical Property of methyl 4-[2-[[2-(2,4-difluorophenoxy)-2-[4-(1-piperidylsulfonyl)phenyl]acetyl]amino]thiazol-5-yl]oxybenzoate

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Technology Process of methyl 4-[2-[[2-(2,4-difluorophenoxy)-2-[4-(1-piperidylsulfonyl)phenyl]acetyl]amino]thiazol-5-yl]oxybenzoate

There total 6 articles about methyl 4-[2-[[2-(2,4-difluorophenoxy)-2-[4-(1-piperidylsulfonyl)phenyl]acetyl]amino]thiazol-5-yl]oxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1001327-29-2
4-(2-amino-thiazol-5-yloxy)benzoic acid methyl ester

: 1328997-88-1
(2,4-difluorophenoxy)-[4-(piperidine-1-sulfonyl)phenyl]acetic acid

: 1328984-50-4,1328992-12-6,1328992-13-7
methyl 4-[2-[[2-(2,4-difluorophenoxy)-2-[4-(1-piperidylsulfonyl)phenyl]acetyl]amino]thiazol-5-yl]oxybenzoate

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 18h; Cooling with ice; Inert atmosphere;
DOI:10.1016/j.ejmech.2017.03.042

Reference yield:

: 39161-84-7
4-mercaptophenylacetic acid

: 1328984-50-4,1328992-12-6,1328992-13-7
methyl 4-[2-[[2-(2,4-difluorophenoxy)-2-[4-(1-piperidylsulfonyl)phenyl]acetyl]amino]thiazol-5-yl]oxybenzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / methanol / 24 h / 20 °C / Inert atmosphere

2.1: potassium nitrate; chloro-trimethyl-silane / dichloromethane / 50 °C / Sealed tube; Inert atmosphere

3.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 48 h / Reflux; Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: caesium carbonate / acetonitrile / 3.5 h / 25 °C / Inert atmosphere

5.1: lithium hydroxide / tetrahydrofuran; methanol; water / 18 h / 20 °C / Inert atmosphere

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 18 h / 20 °C / Cooling with ice; Inert atmosphere

With 4-methyl-morpholine; N-Bromosuccinimide; chloro-trimethyl-silane; sulfuric acid; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium nitrate; lithium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; acetonitrile;
DOI:10.1016/j.ejmech.2017.03.042

Reference yield:

: 91361-92-1
(4-mercapto-phenyl)-acetic acid methyl ester

: 1328984-50-4,1328992-12-6,1328992-13-7
methyl 4-[2-[[2-(2,4-difluorophenoxy)-2-[4-(1-piperidylsulfonyl)phenyl]acetyl]amino]thiazol-5-yl]oxybenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium nitrate; chloro-trimethyl-silane / dichloromethane / 50 °C / Sealed tube; Inert atmosphere

2.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 48 h / Reflux; Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

3.1: caesium carbonate / acetonitrile / 3.5 h / 25 °C / Inert atmosphere

4.1: lithium hydroxide / tetrahydrofuran; methanol; water / 18 h / 20 °C / Inert atmosphere

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 18 h / 20 °C / Cooling with ice; Inert atmosphere

With 4-methyl-morpholine; N-Bromosuccinimide; chloro-trimethyl-silane; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium nitrate; lithium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; acetonitrile;
DOI:10.1016/j.ejmech.2017.03.042