[(Z)-3-Methoxy-10-(toluene-4-sulfonyl)-9,10-dihydro-8H-7-thia-5,10-diaza-benzocycloocten-6-yl]-(2-pyrrolidin-1-yl-ethyl)-amine; hydrobromide

Base Information

Chemical Name:[(Z)-3-Methoxy-10-(toluene-4-sulfonyl)-9,10-dihydro-8H-7-thia-5,10-diaza-benzocycloocten-6-yl]-(2-pyrrolidin-1-yl-ethyl)-amine; hydrobromide
CAS No.:86670-87-3
Molecular Formula:BrH*C₂₃H₃₀N₄O₃S₂
Molecular Weight:555.56
Hs Code.:

[(Z)-3-Methoxy-10-(toluene-4-sulfonyl)-9,10-dihydro-8H-7-thia-5,10-diaza-benzocycloocten-6-yl]-(2-pyrrolidin-1-yl-ethyl)-amine; hydrobromide

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Chemical Property of [(Z)-3-Methoxy-10-(toluene-4-sulfonyl)-9,10-dihydro-8H-7-thia-5,10-diaza-benzocycloocten-6-yl]-(2-pyrrolidin-1-yl-ethyl)-amine; hydrobromide

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Technology Process of [(Z)-3-Methoxy-10-(toluene-4-sulfonyl)-9,10-dihydro-8H-7-thia-5,10-diaza-benzocycloocten-6-yl]-(2-pyrrolidin-1-yl-ethyl)-amine; hydrobromide

There total 4 articles about [(Z)-3-Methoxy-10-(toluene-4-sulfonyl)-9,10-dihydro-8H-7-thia-5,10-diaza-benzocycloocten-6-yl]-(2-pyrrolidin-1-yl-ethyl)-amine; hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 86662-11-5
N-(2-bromoethyl)-2'-isothiocyanato-4'-methoxytosylanilide

: 86670-87-3
[(Z)-3-Methoxy-10-(toluene-4-sulfonyl)-9,10-dihydro-8H-7-thia-5,10-diaza-benzocycloocten-6-yl]-(2-pyrrolidin-1-yl-ethyl)-amine; hydrobromide

Guidance literature:: In diethyl ether; for 3h; Heating;
DOI:10.1016/S0040-4020(01)91886-1

Reference yield:

: 3360-81-4
N-(4-methoxy-2-nitrophenyl)-4-methylbenzenesulfonamide

: 86670-87-3
[(Z)-3-Methoxy-10-(toluene-4-sulfonyl)-9,10-dihydro-8H-7-thia-5,10-diaza-benzocycloocten-6-yl]-(2-pyrrolidin-1-yl-ethyl)-amine; hydrobromide

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / K₂CO₃ / dimethylformamide / on steam bath

2: 76 percent / H₂ / 5percent Pd-C / ethanol; dioxane / Ambient temperature

3: 89 percent / H₂O / 1) 0 deg C, 2 h, 2) 4 deg C, several hours

4: 68 percent / diethyl ether / 3 h / Heating

With hydrogen; potassium carbonate; palladium on activated charcoal; In 1,4-dioxane; diethyl ether; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)91886-1

Reference yield:

: 16058-88-1
N-(2-Bromoethyl)-N-tosyl-4-methoxy-2-nitraniline

: 86670-87-3
[(Z)-3-Methoxy-10-(toluene-4-sulfonyl)-9,10-dihydro-8H-7-thia-5,10-diaza-benzocycloocten-6-yl]-(2-pyrrolidin-1-yl-ethyl)-amine; hydrobromide

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / H₂ / 5percent Pd-C / ethanol; dioxane / Ambient temperature

2: 89 percent / H₂O / 1) 0 deg C, 2 h, 2) 4 deg C, several hours

3: 68 percent / diethyl ether / 3 h / Heating

With hydrogen; palladium on activated charcoal; In 1,4-dioxane; diethyl ether; ethanol; water;
DOI:10.1016/S0040-4020(01)91886-1