3,8-Diazabicyclo[3.2.1]octane-6-carboxylic acid, 3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-phenylethyl]-8-methyl-2,4-dioxo-, ethyl ester, [1S-[1alpha,3(R*),5alpha,6alpha]]-

Base Information

Chemical Name:3,8-Diazabicyclo[3.2.1]octane-6-carboxylic acid, 3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-phenylethyl]-8-methyl-2,4-dioxo-, ethyl ester, [1S-[1alpha,3(R*),5alpha,6alpha]]-
CAS No.:127420-41-1
Molecular Formula:C₂₄H₃₆N₂O₅Si
Molecular Weight:460.646
Hs Code.:
DSSTox Substance ID:DTXSID301099390

3,8-Diazabicyclo[3.2.1]octane-6-carboxylic acid, 3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-phenylethyl]-8-methyl-2,4-dioxo-, ethyl ester, [1S-[1alpha,3(R*),5alpha,6alpha]]-

Synonyms:DTXSID301099390;127420-41-1;3,8-Diazabicyclo[3.2.1]octane-6-carboxylic acid, 3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-phenylethyl]-8-methyl-2,4-dioxo-, ethyl ester, [1S-[1alpha,3(R*),5alpha,6alpha]]-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,8-Diazabicyclo[3.2.1]octane-6-carboxylic acid, 3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-phenylethyl]-8-methyl-2,4-dioxo-, ethyl ester, [1S-[1alpha,3(R*),5alpha,6alpha]]-

Chemical Property:

Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:460.23934879
Heavy Atom Count:32
Complexity:728

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1CC2C(=O)N(C(=O)C1N2C)C(CO[Si](C)(C)C(C)(C)C)C3=CC=CC=C3
Isomeric SMILES:CCOC(=O)[C@@H]1C[C@H]2C(=O)N(C(=O)[C@@H]1N2C)[C@H](CO[Si](C)(C)C(C)(C)C)C3=CC=CC=C3

Technology Process of 3,8-Diazabicyclo[3.2.1]octane-6-carboxylic acid, 3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-phenylethyl]-8-methyl-2,4-dioxo-, ethyl ester, [1S-[1alpha,3(R*),5alpha,6alpha]]-

There total 4 articles about 3,8-Diazabicyclo[3.2.1]octane-6-carboxylic acid, 3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-phenylethyl]-8-methyl-2,4-dioxo-, ethyl ester, [1S-[1alpha,3(R*),5alpha,6alpha]]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 64-17-5
ethanol

: 127470-57-9
<3aR<1<1S^*,3(R^*),5R^*,6R^*>,3aα,6α,7aβ>>-1-<<3-<2-<<(1,1-Dimwthylethyl)dimethylsilyl>oxy>-1-phenylethyl>-8-methyl-2,4-dioxo-3,8-diazabicyclo<3.2.1>oct-6-yl>carbonyl>hexahydro-8,8-dimethyl-3H-3a,6-methano-2,1-benzisothiazole 2,2-dioxide

: 108448-77-7,124224-04-0
(+)-camphorsultam

: 127420-41-1
<1S<1α,3(R^*),5α,6α>>-3-<2-<<(1,1-Dimethylethyl)dimethylsilyl>oxy>-1-phenylethyl>-8-methyl-2,4-dioxo-3,8-diazabicyclo<3.2.1>octane-6-carboxylic acid ethyl ester

Guidance literature:: With titanium(IV) isopropylate; for 23h; Yields of byproduct given; Heating;
DOI:10.1021/jo00020a035

Reference yield:

: 127381-60-6
(S)-3-<2-<<(1,1-Dimethylethyl)dimethylsilyl>oxy>-1-phenylethyl>-6-methyl-3,6-diazabicyclo<3.1.0>hexane-2,4-dione

: 127420-41-1
<1S<1α,3(R^*),5α,6α>>-3-<2-<<(1,1-Dimethylethyl)dimethylsilyl>oxy>-1-phenylethyl>-8-methyl-2,4-dioxo-3,8-diazabicyclo<3.2.1>octane-6-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / dioxane / Irradiation; continuous slow addition of dipolarophile

2: 51 percent / Ti(OiPr)4 / 23 h / Heating

With titanium(IV) isopropylate; In 1,4-dioxane;
DOI:10.1021/jo00020a035

Reference yield:

: 120417-16-5,135557-52-7,135557-53-8
5-<(S)-2-<<(1,1-Dimethylethyl)dimethylsilyll>oxy>-1-phenylethyl>-3a,6a-dihydro-1-methylpyrrolo<3,4-d>-1,2,3-triazole-4,6(1H,5H)-dione

: 127420-41-1
<1S<1α,3(R^*),5α,6α>>-3-<2-<<(1,1-Dimethylethyl)dimethylsilyl>oxy>-1-phenylethyl>-8-methyl-2,4-dioxo-3,8-diazabicyclo<3.2.1>octane-6-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / dioxane / 5 h / Irradiation

2: 53 percent / dioxane / Irradiation; continuous slow addition of dipolarophile

3: 51 percent / Ti(OiPr)4 / 23 h / Heating

With titanium(IV) isopropylate; In 1,4-dioxane;
DOI:10.1021/jo00020a035