solasodine-3β-acetate

Base Information

• Chemical Name: solasodine-3β-acetate
• CAS No.: 1415-78-7
• Molecular Formula: C₂₉H₄₅NO₃
• Molecular Weight: 455.681
• Mol file: 1415-78-7.mol

Synonyms:

Chemical Property of solasodine-3β-acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of solasodine-3β-acetate

There total 11 articles about solasodine-3β-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

5,6-epoxy-solasodine-3β-acteate → solasodine-3β-acetate (1415-78-7,6159-99-5)

Guidance literature:

With iodine; triphenylphosphine; In dichloromethane; at 25 ℃; for 1h;

DOI:10.1016/j.steroids.2012.05.002

Reference yield: 69.0%

C29H43N3O3 (1000612-51-0) → tomatidenol acetate + solasodine-3β-acetate (1415-78-7,6159-99-5)

Guidance literature:

C₂₉H₄₃N₃O₃; With sodium iodide; In acetonitrile; for 0.5h; Inert atmosphere;

With chloro-trimethyl-silane; In acetonitrile; at 20 ℃; for 11h; Inert atmosphere;

DOI:10.1016/j.tetlet.2015.01.149

Reference yield:

diosgenin acetate (1061-54-7) → solasodine-3β-acetate (1415-78-7,6159-99-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium bromide; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / 3 h / 25 °C / Inert atmosphere

1.2: 2 h / 65 °C / Inert atmosphere

2.1: sodium azide / 5 h / 60 °C / Inert atmosphere

3.1: sodium iodide / acetonitrile / 0.5 h / Inert atmosphere

3.2: 11 h / 20 °C / Inert atmosphere

With sodium azide; boron trifluoride diethyl etherate; sodium iodide; lithium bromide; In dichloromethane; acetonitrile;

DOI:10.1016/j.tetlet.2015.01.149

upstream raw materials:

acetic anhydride

solasodine

acetic acid

solasonine

Downstream raw materials:

solasodine

16-dehydropregnenolone acetate

solasodine N,O-diacetate