(S)-2-{4-[(2-Amino-3-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid; compound with trifluoro-acetic acid

Base Information

Chemical Name:(S)-2-{4-[(2-Amino-3-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid; compound with trifluoro-acetic acid
CAS No.:127117-60-6
Molecular Formula:C₂HF₃O₂*C₂₅H₂₅N₅O₆
Molecular Weight:605.527
Hs Code.:

(S)-2-{4-[(2-Amino-3-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid; compound with trifluoro-acetic acid

Synonyms:

Suppliers and Price of (S)-2-{4-[(2-Amino-3-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid; compound with trifluoro-acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-2-{4-[(2-Amino-3-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid; compound with trifluoro-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-2-{4-[(2-Amino-3-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid; compound with trifluoro-acetic acid

There total 5 articles about (S)-2-{4-[(2-Amino-3-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid; compound with trifluoro-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 127117-59-3
di-t-butyl N-(4-(N-((2-amino-3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)methyl)prop-2-ynylamino)benzoyl)-L-glutamate

: 76-05-1
trifluoroacetic acid

: 127117-60-6
(S)-2-{4-[(2-Amino-3-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid; compound with trifluoro-acetic acid

Guidance literature:: at 25 ℃; for 1h;
DOI:10.1002/jhet.5570260548

Reference yield:

: 77766-62-2
2-amino-6-(bromomethyl)-4-hydroxyquinazoline hydrobromide

: 127117-60-6
(S)-2-{4-[(2-Amino-3-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / DMA, CaCO₃ / 96 h / 25 °C

2: 33 percent / K₂CO₃ / methanol / 45 h / 25 °C

3: 72 percent / 1 h / 25 °C

With 2,4-dichlorophenoxyacetic acid dimethylamine; potassium carbonate; calcium carbonate; In methanol;
DOI:10.1002/jhet.5570260548

Reference yield:

: 112888-47-8
di-tert-butyl N-<4-(prop-2-ynylamino)benzoyl>-L-glutamate

: 127117-60-6
(S)-2-{4-[(2-Amino-3-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / DMA, CaCO₃ / 96 h / 25 °C

2: 33 percent / K₂CO₃ / methanol / 45 h / 25 °C

3: 72 percent / 1 h / 25 °C

With 2,4-dichlorophenoxyacetic acid dimethylamine; potassium carbonate; calcium carbonate; In methanol;
DOI:10.1002/jhet.5570260548