L-Glutamic acid, N-(4-aminobenzoyl)-, bis(1,1-dimethylethyl) ester

Base Information

Chemical Name:L-Glutamic acid, N-(4-aminobenzoyl)-, bis(1,1-dimethylethyl) ester
CAS No.:76282-66-1
Molecular Formula:C20H30N2O5
Molecular Weight:378.469
Hs Code.:
DSSTox Substance ID:DTXSID50443589
Wikidata:Q82261480

Synonyms:76282-66-1;L-Glutamic acid, N-(4-aminobenzoyl)-, bis(1,1-dimethylethyl) ester;SCHEMBL9087244;DTXSID50443589;YMDRIHSBRRVQHR-HNNXBMFYSA-N;4-aminobenzoylglutamic acid di-t-butyl ester;4-aminobenzoyl-glutamic acid di-t-butyl ester;di-tert-butyl N-(4-aminobenzoyl)-L-glutamate

Suppliers and Price of L-Glutamic acid, N-(4-aminobenzoyl)-, bis(1,1-dimethylethyl) ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of L-Glutamic acid, N-(4-aminobenzoyl)-, bis(1,1-dimethylethyl) ester

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:10
Exact Mass:378.21547206
Heavy Atom Count:27
Complexity:526

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)CCC(C(=O)OC(C)(C)C)NC(=O)C1=CC=C(C=C1)N
Isomeric SMILES:CC(C)(C)OC(=O)CC[C@@H](C(=O)OC(C)(C)C)NC(=O)C1=CC=C(C=C1)N

Technology Process of L-Glutamic acid, N-(4-aminobenzoyl)-, bis(1,1-dimethylethyl) ester

There total 8 articles about L-Glutamic acid, N-(4-aminobenzoyl)-, bis(1,1-dimethylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 32677-01-3
L-glutamic acid di-tert-butyl ester hydrochloride

: 150-13-0,159246-81-8,8014-65-1
4-amino-benzoic acid

: 76282-66-1
di-tert-butyl (S)-N-(p-aminobenzoyl)-glutamate

Guidance literature:: With triethylamine; diethyl dicarbonate; In N,N-dimethyl-formamide; for 1h; Ambient temperature;
DOI:10.1248/cpb.46.255

Reference yield: 87.0%

: 88050-23-1
Di-tert-butyl 4-nitrobenzoyl-L-glutamate

: 76282-66-1
Di-tert-butyl 4-aminobenzoyl-L-glutamate

Guidance literature:: With ammonium formate; palladium on activated charcoal; In methanol; for 0.5h; Ambient temperature;
DOI:10.1016/S0040-4020(01)87844-3

Reference yield:

: 16874-06-9
di-tert-butyl L-glutamate

: 76282-66-1
di-tert-butyl (S)-N-(p-aminobenzoyl)-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / H₂O; CH₂Cl₂ / 18 h / 0 - 10 °C

2: 99 percent / H₂ / Pd/C / methanol / 3 h / 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; dichloromethane; water;
DOI:10.1021/jo030049y