Technology Process of 2-[3-(2,2-Dimethoxy-ethyl)-2,4,8-trioxo-6-phenyl-2,3,4,8-tetrahydro-1H-pyrido[3,4-d]pyrimidin-7-yl]-N-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propyl)-acetamide
There total 13 articles about 2-[3-(2,2-Dimethoxy-ethyl)-2,4,8-trioxo-6-phenyl-2,3,4,8-tetrahydro-1H-pyrido[3,4-d]pyrimidin-7-yl]-N-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propyl)-acetamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
for 2h;
Ambient temperature;
DOI:10.1021/jm950684z
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 1.) NaH / 1.) THF, hexane, RT, 4.5 h, 2.) THF, hexane, RT, 1 h
2: 48 percent / 24 h / 120 °C / 1 Torr
3: 96 percent / LiI / pyridine / 14 h / Heating
4: 84 percent / diphenyl phosphoroazidate, TEA / dioxane / 4 h / Heating
5: 53 percent / aq. LiOH*H2O / ethanol / 7 h / 0 °C
6: HOBt, EDAC / dimethylformamide / 16 h / Ambient temperature
7: dimethylformamide / 2.5 h / 120 °C
8: TBAF / tetrahydrofuran / 2 h / Ambient temperature
With
lithium hydroxide; TEA; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium iodide;
In
tetrahydrofuran; 1,4-dioxane; pyridine; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm950684z
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 1.) NaH / 1.) THF, hexane, RT, 4.5 h, 2.) THF, hexane, RT, 1 h
2: 48 percent / 24 h / 120 °C / 1 Torr
3: 96 percent / LiI / pyridine / 14 h / Heating
4: 84 percent / diphenyl phosphoroazidate, TEA / dioxane / 4 h / Heating
5: 53 percent / aq. LiOH*H2O / ethanol / 7 h / 0 °C
6: HOBt, EDAC / dimethylformamide / 16 h / Ambient temperature
7: dimethylformamide / 2.5 h / 120 °C
8: TBAF / tetrahydrofuran / 2 h / Ambient temperature
With
lithium hydroxide; TEA; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium iodide;
In
tetrahydrofuran; 1,4-dioxane; pyridine; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm950684z
![N-[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propyl]-2-[3-(2,2-dimethoxy-ethyl)-2,4,8-trioxo-6-phenyl-2,3,4,8-tetrahydro-1H-pyrido[3,4-d]pyrimidin-7-yl]-acetamide](/Databaselist/images/loading.webp)
