[(2R,3S,5R)-5-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl]-carbamic acid (2R,3S,5R)-2-aminomethyl-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester; compound with toluene-4-sulfonic acid

Base Information

• Chemical Name: [(2R,3S,5R)-5-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl]-carbamic acid (2R,3S,5R)-2-aminomethyl-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester; compound with toluene-4-sulfonic acid
• CAS No.: 109979-04-6
• Molecular Formula: C₇H₈O₃S*C₃₃H₃₄N₈O₉
• Molecular Weight: 858.886

Synonyms:

Chemical Property of [(2R,3S,5R)-5-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl]-carbamic acid (2R,3S,5R)-2-aminomethyl-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester; compound with toluene-4-sulfonic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(2R,3S,5R)-5-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl]-carbamic acid (2R,3S,5R)-2-aminomethyl-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester; compound with toluene-4-sulfonic acid

There total 5 articles about [(2R,3S,5R)-5-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl]-carbamic acid (2R,3S,5R)-2-aminomethyl-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester; compound with toluene-4-sulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5'-azido-2',5'-dideoxy-N4-benzoylcytidine (74597-69-6) → [(2R,3S,5R)-5-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl]-carbamic acid (2R,3S,5R)-2-aminomethyl-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester; compound with toluene-4-sulfonic acid (109979-04-6)

Guidance literature:

Multi-step reaction with 5 steps

1: H₂ / 10percent Pd/C / ethanol; dimethylformamide; acetic acid / 18.5 h / 1810.02 Torr

2: pyridine, Et₃N / 4 h

3: 67 percent / Et₃N / dimethylformamide / 2.5 h

4: Et₃N / dimethylformamide

5: AcOH / methanol / 5 h / Ambient temperature

With pyridine; hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In methanol; ethanol; acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/jo00228a010

Reference yield:

N4-benzoyl-2',5'-dideoxy-5'-(4''-monomethoxytrityl)aminocytidine (109979-00-2) → [(2R,3S,5R)-5-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl]-carbamic acid (2R,3S,5R)-2-aminomethyl-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester; compound with toluene-4-sulfonic acid (109979-04-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 67 percent / Et₃N / dimethylformamide / 2.5 h

2: Et₃N / dimethylformamide

3: AcOH / methanol / 5 h / Ambient temperature

With acetic acid; triethylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jo00228a010

Reference yield:

p-nitrophenyl N4-benzoyl-2',5'-dideoxy-5'-(4''-monomethoxytrityl)aminocytidine 3'-carbonate (109205-80-3) → [(2R,3S,5R)-5-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl]-carbamic acid (2R,3S,5R)-2-aminomethyl-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester; compound with toluene-4-sulfonic acid (109979-04-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / dimethylformamide

2: AcOH / methanol / 5 h / Ambient temperature

With acetic acid; triethylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jo00228a010

upstream raw materials:

toluene-4-sulfonic acid

N⁴-benzoyl-2',5'-dideoxy-5'-(4''-monomethoxytrityl)aminocytidylyl-(3'-5''-carbamoyl)-5'-amino-N⁴-benzoyl-2',5'-dideoxycytidine

N⁴-benzoyl-2',5'-dideoxy-5'-(4''-monomethoxytrityl)aminocytidine

p-nitrophenyl N⁴-benzoyl-2',5'-dideoxy-5'-(4''-monomethoxytrityl)aminocytidine 3'-carbonate

Downstream raw materials:

N⁴-benzoyl-2',5'-dideoxy-5'-(4''-monomethoxytrityl)aminocytidylyl-(3'-5''-carbamoyl)-<5'-amino-N⁴-benzoyl-2',5'-dideoxycytidylyl-(3'-5'-carbamoyl)>2-5'-amino-N⁴-benzoyl-2',5'-dideoxycytidine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 109979-04-6 [(2R,3S,5R)-5-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl]-carbamic acid (2R,3S,5R)-2-aminomethyl-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester; compound with toluene-4-sulfonic acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send