74597-69-6

Upstream product

• 4836-13-9 N₄-benzoyl-2'-deoxycytidine 
• 951-77-9 2'-Deoxycytidine 
• 98-88-4 benzoyl chloride 

Downstream Products

• 109205-80-3 p-nitrophenyl N⁴-benzoyl-2',5'-dideoxy-5'-(4''-monomethoxytrityl)aminocytidine 3'-carbonate 
• 109979-01-3 N⁴-benzoyl-2',5'-dideoxy-5'-(4''-monomethoxytrityl)aminocytidylyl-(3'-5''-carbamoyl)-5'-amino-N⁴-benzoyl-2',5'-dideoxycytidine 
• 109979-02-4 4-nitrophenyl N⁴-benzoyl-2',5'-dideoxy-5'-(4''-monomethoxytrityl)aminocytidylyl-(3'-5''-carbamoyl)-5'-amino-N⁴-benzoyl-2',5'-dideoxycytidine 3'-carbonate 
• 109979-04-6 [(2R,3S,5R)-5-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl]-carbamic acid (2R,3S,5R)-2-aminomethyl-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester; compound with toluene-4-sulfonic acid 
• 1401429-78-4 dibenzyl 5'-azido-4-(N-benzoyl)-2',5'-dideoxycytidine 3'-monophosphate 
• 109979-00-2 N⁴-benzoyl-2',5'-dideoxy-5'-(4''-monomethoxytrityl)aminocytidine 
• 109978-98-5 5'-amino-N⁴-benzoyl-2',5'-dideoxycytidine 

Relevant academic research and scientific papers

DNG cytidine: Synthesis and binding properties of octameric guanidinium-linked deoxycytidine oligomer

The synthesis of guanidinium-linked cytidyl oligomer (DNG-C8), a cationic DNA analog, and the corresponding cytidine monomers is described. The DNG monomer synthesis was streamlined to produce a shorter route to the final monomer than previously reported for thymidine and subsequent solid-phase synthesis produced an octameric cytidyl DNG strand. Because octameric deoxyguanosine would be used as the complementary strand in our studies, it was necessary to investigate guanosine self-association. Singular value decomposition was used to mathematically deconvolve the spectral data and confirm the presence of transitions due to DNA-G8 self-association. Job plots show the binding stoichiometry of DNG-C8 with DNA-G 8 to be 1:1. Thermal denaturation studies of the DNG-C 8·DNA-G8 duplex established a T m≥90°C and a ΔG°=-13.3kcalmol-1, indicating the DNG-C8·DNA-G8 duplex is over 1000 times more stable than that of DNA-C8·DNA-G8.

One-Step Synthesis of 5'-Azido-nucleosides

Regioselective azidation of unprotected or appropriately protected nucleosides was conducted by means of the reagent triphenylphosphine-carbon tetrabromide-lithium azide.By use of this reagent, 5'-azido-5'-deoxynucleosides were prepared conveniently in one step from nucleosides in high yields.Secondary hydroxy-groups of appropriately 5'-protected nucleosides were also converted by the reagent to azido-functions with complete inversion.