Technology Process of C11H9Cl2NO3
There total 3 articles about C11H9Cl2NO3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tert-Butyl N-hydroxycarbamate; Methyl-3,4-dichlorbenzylidenpyruvat;
With
3-(3,5-bis-trifluoromethyl-phenylamino)-4-{[(S)-(6-methoxy-quinolin-4-yl)-((R)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methyl]-amino}-cyclobut-3-ene-1,2-dione;
In
toluene;
at 20 ℃;
for 24h;
Schlenk technique;
With
trifluoroacetic acid;
In
toluene;
for 1h;
Overall yield = 36 %; Overall yield = 29 mg; Optical yield = 8 %ee; chemoselective reaction;
Schlenk technique;
DOI:10.1039/c3ob42406e
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: boron trifluoride diethyl etherate / dichloromethane / 0.5 h / -78 °C / Inert atmosphere
1.2: 2.5 h / -30 - 30 °C
2.1: silica gel / toluene / 3 h / Reflux
3.1: 3-(3,5-bis-trifluoromethyl-phenylamino)-4-{[(S)-(6-methoxy-quinolin-4-yl)-((R)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methyl]-amino}-cyclobut-3-ene-1,2-dione / toluene / 24 h / 20 °C / Schlenk technique
3.2: 1 h / Schlenk technique
With
3-(3,5-bis-trifluoromethyl-phenylamino)-4-{[(S)-(6-methoxy-quinolin-4-yl)-((R)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methyl]-amino}-cyclobut-3-ene-1,2-dione; boron trifluoride diethyl etherate; silica gel;
In
dichloromethane; toluene;
DOI:10.1039/c3ob42406e
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: silica gel / toluene / 3 h / Reflux
2.1: 3-(3,5-bis-trifluoromethyl-phenylamino)-4-{[(S)-(6-methoxy-quinolin-4-yl)-((R)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methyl]-amino}-cyclobut-3-ene-1,2-dione / toluene / 24 h / 20 °C / Schlenk technique
2.2: 1 h / Schlenk technique
With
3-(3,5-bis-trifluoromethyl-phenylamino)-4-{[(S)-(6-methoxy-quinolin-4-yl)-((R)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methyl]-amino}-cyclobut-3-ene-1,2-dione; silica gel;
In
toluene;
DOI:10.1039/c3ob42406e
