THIAZOLIDINE-2-CARBOXYLIC ACID

Base Information

• Chemical Name: THIAZOLIDINE-2-CARBOXYLIC ACID
• CAS No.: 16310-13-7
• Molecular Formula: C4H7 N O2 S
• Molecular Weight: 133.171
• Hs Code.: 29341000
• Mol file: 16310-13-7.mol

Synonyms:(?à)-2-Thiazolidinecarboxylic acid;DL-Thiazolidine-2-carboxylic acid; b-Thiaproline

Chemical Property of THIAZOLIDINE-2-CARBOXYLIC ACID

Chemical Property:

• Appearance/Colour: white powder
• Vapor Pressure: 7.63E-06mmHg at 25°C
• Melting Point: 179-184 ºC
• Boiling Point: 350.3°C at 760 mmHg
• PKA: 1.38±0.20(Predicted)
• Flash Point: 165.7°C
• PSA: 74.63000
• Density: 1.38g/cm³
• LogP: 0.06230
• Water Solubility.: very faint turbidity

Purity/Quality:

98%,99%, ^*data from raw suppliers

rac-2-?Thiazolidinecarboxyl?icAcid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 36/37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: rac-2-?Thiazolidinecarboxyl?ic Acid is a derivative of thiazolidyne-?4-?carboxylic acid (thiaproline) (T344205) and can be used as a colouring agent. Futhermore, it may be a physiological substrate for D-?amino acid oxidase.

Technology Process of THIAZOLIDINE-2-CARBOXYLIC ACID

There total 4 articles about THIAZOLIDINE-2-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-mercaptoethylamine hydrochloride (156-57-0) + Glyoxilic acid (298-12-4) → DL-3-thiazolidine-4-carboxylic acid (16310-13-7,65126-70-7)

Guidance literature:

With pyridine; In ethanol; for 2h;

DOI:10.1021/jm00402a030

Reference yield: 92.0%

Cysteamine (60-23-1) + Glyoxilic acid (298-12-4) → DL-3-thiazolidine-4-carboxylic acid (16310-13-7,65126-70-7)

Guidance literature:

With pyridine; In ethanol;

DOI:10.1021/acs.bioconjchem.6b00667

Reference yield:

2,2-diethoxy acetic acid (20461-86-3) + Cysteamine (60-23-1) → DL-3-thiazolidine-4-carboxylic acid (16310-13-7,65126-70-7)

Guidance literature:

With ethanol;

upstream raw materials:

2,2-diethoxy acetic acid

Cysteamine

Glyoxilic acid

2-mercaptoethylamine hydrochloride

Downstream raw materials:

Thiazolidine-2-carboxylic Acid Methyl Ester

Refernces

• 1、 Nagase,Yukawa,Inomata,Takeuchi. "Synthetic, spectroscopic and X-ray crystallographic studies of bivalent metal complexes with amino acids having a thiazolidine ring. III. The properties of bivalent metal complexes with racemic 2-thiazolidinecarboxylic acid and the structure of trans-diaquabis-(2-thiazolidinecarboxylato)zinc(II)". . p. 3247 - 3251. Retrieved 1989.
• 2、 -. "BIOCONJUGATION OF POLYPEPTIDES". Page/Page column 58; 63. . Retrieved 2019/04/26.
• 3、 Bi, Xiaobao,Pasunooti, Kalyan Kumar,Lescar, Julien,Liu, Chuan-Fa. "Thiazolidine-Masked α-Oxo Aldehyde Functionality for Peptide and Protein Modification". . p. 325 - 329. Retrieved 2017/02/23.