2-((2-methoxy-5-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)amino)-5,11-dimethyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one

Base Information

Chemical Name:2-((2-methoxy-5-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)amino)-5,11-dimethyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one
CAS No.:1234480-88-6
Molecular Formula:C₃₁H₃₈N₈O₃
Molecular Weight:570.695
Hs Code.:

2-((2-methoxy-5-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)amino)-5,11-dimethyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one

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Chemical Property of 2-((2-methoxy-5-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)amino)-5,11-dimethyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one

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Technology Process of 2-((2-methoxy-5-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)amino)-5,11-dimethyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one

There total 4 articles about 2-((2-methoxy-5-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)amino)-5,11-dimethyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1234479-75-4
2-chloro-5,11-dimethyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one

: C₁₈H₂₈N₄O₂

: 1234480-88-6
2-((2-methoxy-5-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)amino)-5,11-dimethyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos; In 1,4-dioxane; at 95 ℃;
DOI:10.1021/acs.jmedchem.0c00596

Reference yield:

: 35472-56-1
N-methyl-anthranilic acid ethyl ester

: 1234480-88-6
2-((2-methoxy-5-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)amino)-5,11-dimethyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 6 h / 50 °C

2: iron; acetic acid / 9 h / 50 °C

3: sodium hydride / N,N-dimethyl acetamide; mineral oil / -10 - 0 °C

4: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / 1,4-dioxane / 95 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iron; sodium hydride; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; XPhos; In 1,4-dioxane; N,N-dimethyl acetamide; mineral oil;
DOI:10.1021/acs.jmedchem.0c00596

Reference yield:

: 1234479-74-3
ethyl 2-((2-chloro-5-nitropyrimidin-4-yl)(methyl)amino)benzoate

: 1234480-88-6
2-((2-methoxy-5-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)amino)-5,11-dimethyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one

Guidance literature:: Multi-step reaction with 3 steps

1: iron; acetic acid / 9 h / 50 °C

2: sodium hydride / N,N-dimethyl acetamide; mineral oil / -10 - 0 °C

3: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / 1,4-dioxane / 95 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iron; sodium hydride; caesium carbonate; acetic acid; XPhos; In 1,4-dioxane; N,N-dimethyl acetamide; mineral oil;
DOI:10.1021/acs.jmedchem.0c00596