2-chloro-5,11-diMethyl-5H-benzo[e]pyriMido[5,4-b][1,4]diazepin-6(11H)-one

Base Information

Chemical Name:2-chloro-5,11-diMethyl-5H-benzo[e]pyriMido[5,4-b][1,4]diazepin-6(11H)-one
CAS No.:1234479-75-4
Molecular Formula:C13H11ClN4O
Molecular Weight:274.71
Hs Code.:
Mol file:1234479-75-4.mol

Synonyms:2-chloro-5,11-diMethyl-5H-benzo[e]pyriMido[5,4-b][1,4]diazepin-6(11H)-one

Suppliers and Price of 2-chloro-5,11-diMethyl-5H-benzo[e]pyriMido[5,4-b][1,4]diazepin-6(11H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
2-Chloro-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one 95%+
1g
$ 1630.00

Chemenu
2-Chloro-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one 95%+
250mg
$ 951.00

Chemenu
2-Chloro-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one 95%+
100mg
$ 611.00

Total 6 raw suppliers

Chemical Property of 2-chloro-5,11-diMethyl-5H-benzo[e]pyriMido[5,4-b][1,4]diazepin-6(11H)-one

Chemical Property:

PSA：52.71000
LogP:2.03580

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-Chloro-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one 95%+ ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-chloro-5,11-diMethyl-5H-benzo[e]pyriMido[5,4-b][1,4]diazepin-6(11H)-one

There total 5 articles about 2-chloro-5,11-diMethyl-5H-benzo[e]pyriMido[5,4-b][1,4]diazepin-6(11H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 66427-86-9
2-chloro-11-methyl-5,11-dihydro-6H-benzo[e]pyrimido-[5,4-b][1,4]diazepin-6-one

: 74-88-4
methyl iodide

: 1234479-75-4
2-chloro-5,11-dimethyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one

Guidance literature:: With sodium hydride; In N,N-dimethyl acetamide; at -10 - 0 ℃; for 1.5h; Inert atmosphere;
DOI:10.1038/onc.2014.225

Reference yield:

: 1234479-74-3
ethyl 2-((2-chloro-5-nitropyrimidin-4-yl)(methyl)amino)benzoate

: 1234479-75-4
2-chloro-5,11-dimethyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one

Guidance literature:: Multi-step reaction with 2 steps

1: iron; acetic acid / 50 °C

2: sodium hydride / N,N-dimethyl acetamide / 0 °C

With iron; sodium hydride; acetic acid; In N,N-dimethyl acetamide;
DOI:10.1021/ml100304b

Reference yield:

: 35472-56-1
N-methyl-anthranilic acid ethyl ester

: 1234479-75-4
2-chloro-5,11-dimethyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 50 °C

2: iron; acetic acid / 50 °C

3: sodium hydride / N,N-dimethyl acetamide / 0 °C

With iron; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; N,N-dimethyl acetamide;
DOI:10.1021/ml100304b