12-Oxo-3α,20β(F)-bis(3-methoxycarbonyl-propionyl-oxy)-pregnan

Base Information

• Chemical Name: 12-Oxo-3α,20β(F)-bis(3-methoxycarbonyl-propionyl-oxy)-pregnan
• CAS No.: 120614-68-8
• Molecular Formula: C₃₁H₄₆O₉
• Molecular Weight: 562.701
• Mol file: 120614-68-8.mol

Synonyms:

Chemical Property of 12-Oxo-3α,20β(F)-bis(3-methoxycarbonyl-propionyl-oxy)-pregnan

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 12-Oxo-3α,20β(F)-bis(3-methoxycarbonyl-propionyl-oxy)-pregnan

There total 5 articles about 12-Oxo-3α,20β(F)-bis(3-methoxycarbonyl-propionyl-oxy)-pregnan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3α,12α-bis(acetoxy)-5Hβ-pregnan-20-one (15991-93-2) → 12-Oxo-3α,20β(F)-bis(3-methoxycarbonyl-propionyl-oxy)-pregnan (120614-68-8)

Guidance literature:

Multi-step reaction with 4 steps

1: LiAlH₄ / diethyl ether

3: diethyl ether

4: CrO₃, AcOH

With chromium(VI) oxide; lithium aluminium tetrahydride; acetic acid; In diethyl ether;

DOI:10.1139/v61-066

Reference yield:

3α,20βF-bis-(3-carboxy-propionyloxy)-5β-pregnan-12α-ol (103800-50-6) → 12-Oxo-3α,20β(F)-bis(3-methoxycarbonyl-propionyl-oxy)-pregnan (120614-68-8)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether

2: CrO₃, AcOH

With chromium(VI) oxide; acetic acid; In diethyl ether;

DOI:10.1139/v61-066

Reference yield:

5β-pregnane-3α,12α,20β-triol (5884-80-0) → 12-Oxo-3α,20β(F)-bis(3-methoxycarbonyl-propionyl-oxy)-pregnan (120614-68-8)

Guidance literature:

Multi-step reaction with 3 steps

2: diethyl ether

3: CrO₃, AcOH

With chromium(VI) oxide; acetic acid; In diethyl ether;

DOI:10.1139/v61-066

upstream raw materials:

12α-Hydroxy-3α,20β(F)-bis-(3-methoxycarbonyl-propionyloxy)-pregnan

3α,12α-bis(acetoxy)-5Hβ-pregnan-20-one

3α,20β_F-bis-(3-carboxy-propionyloxy)-5β-pregnan-12α-ol

5β-pregnane-3α,12α,20β-triol

Downstream raw materials:

3α,20β_F-bis-(3-methoxycarbonyl-propionyloxy)-5β-pregn-9(11)-en-12-one