12α-Hydroxy-3α,20β(F)-bis-(3-methoxycarbonyl-propionyloxy)-pregnan

Base Information

• Chemical Name: 12α-Hydroxy-3α,20β(F)-bis-(3-methoxycarbonyl-propionyloxy)-pregnan
• CAS No.: 120831-10-9
• Molecular Formula: C₃₁H₄₈O₉
• Molecular Weight: 564.717
• Mol file: 120831-10-9.mol

Synonyms:

Chemical Property of 12α-Hydroxy-3α,20β(F)-bis-(3-methoxycarbonyl-propionyloxy)-pregnan

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 12α-Hydroxy-3α,20β(F)-bis-(3-methoxycarbonyl-propionyloxy)-pregnan

There total 3 articles about 12α-Hydroxy-3α,20β(F)-bis-(3-methoxycarbonyl-propionyloxy)-pregnan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3α,12α-bis(acetoxy)-5Hβ-pregnan-20-one (15991-93-2) → 12α-Hydroxy-3α,20β(F)-bis-(3-methoxycarbonyl-propionyloxy)-pregnan (120831-10-9)

Guidance literature:

Multi-step reaction with 3 steps

1: LiAlH₄; THF

2: pyridine

3: diethyl ether

With tetrahydrofuran; pyridine; lithium aluminium tetrahydride; diethyl ether;

DOI:10.1139/v59-295

Reference yield:

5β-pregnane-3α,12α,20β-triol (5884-80-0) → 12α-Hydroxy-3α,20β(F)-bis-(3-methoxycarbonyl-propionyloxy)-pregnan (120831-10-9)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: diethyl ether

With pyridine; diethyl ether;

DOI:10.1139/v59-295

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + 3α,20βF-bis-(3-carboxy-propionyloxy)-5β-pregnan-12α-ol (103800-50-6) → 12α-Hydroxy-3α,20β(F)-bis-(3-methoxycarbonyl-propionyloxy)-pregnan (120831-10-9)

Guidance literature:

With diethyl ether;

DOI:10.1139/v59-295

upstream raw materials:

diazomethane

3α,20β_F-bis-(3-carboxy-propionyloxy)-5β-pregnan-12α-ol

3α,12α-bis(acetoxy)-5Hβ-pregnan-20-one

5β-pregnane-3α,12α,20β-triol

Downstream raw materials:

12-Oxo-3α,20β(F)-bis(3-methoxycarbonyl-propionyl-oxy)-pregnan