(9H-fluoren-9-yl)methyl N-(2-((4-(4-(3-bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1,2,5-oxadiazol-3-yl)amino)ethyl)sulfamoylcarbamate

Base Information

• Chemical Name: (9H-fluoren-9-yl)methyl N-(2-((4-(4-(3-bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1,2,5-oxadiazol-3-yl)amino)ethyl)sulfamoylcarbamate
• CAS No.: 1771804-78-4
• Molecular Formula: C₂₇H₂₁BrFN₇O₇S
• Molecular Weight: 686.475
• Mol file: 1771804-78-4.mol

Synonyms:

Chemical Property of (9H-fluoren-9-yl)methyl N-(2-((4-(4-(3-bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1,2,5-oxadiazol-3-yl)amino)ethyl)sulfamoylcarbamate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (9H-fluoren-9-yl)methyl N-(2-((4-(4-(3-bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1,2,5-oxadiazol-3-yl)amino)ethyl)sulfamoylcarbamate

There total 3 articles about (9H-fluoren-9-yl)methyl N-(2-((4-(4-(3-bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1,2,5-oxadiazol-3-yl)amino)ethyl)sulfamoylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.1%

3‐(4‐amino‐1,2,5‐oxadiazol‐3‐yl)‐4‐(3‐bromo‐4‐fluorophenyl)‐1,2,4‐oxadiazol‐5‐one (914471-43-5) + 9H-fluoren-9-ylmethyl{[(2,2-dimethoxyethyl)amino]sulfonyl}carbamate → (9H-fluoren-9-yl)methyl N-(2-((4-(4-(3-bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1,2,5-oxadiazol-3-yl)amino)ethyl)sulfamoylcarbamate (1771804-78-4)

Guidance literature:

3‐(4‐amino‐1,2,5‐oxadiazol‐3‐yl)‐4‐(3‐bromo‐4‐fluorophenyl)‐1,2,4‐oxadiazol‐5‐one; With triethylsilane; methanesulfonic acid; In dichloromethane; at 20 ℃; for 0.166667h;

9H-fluoren-9-ylmethyl{[(2,2-dimethoxyethyl)amino]sulfonyl}carbamate; at 13 - 22 ℃; for 98h;

Reference yield:

9-Fluorenylmethanol (24324-17-2) → (9H-fluoren-9-yl)methyl N-(2-((4-(4-(3-bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1,2,5-oxadiazol-3-yl)amino)ethyl)sulfamoylcarbamate (1771804-78-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloromethane / 2.12 h / 0 - 5 °C

1.2: 2.68 h / 0 - 5 °C

2.1: methanesulfonic acid; triethylsilane / dichloromethane / 0.17 h / 20 °C

2.2: 98 h / 13 - 22 °C

With triethylsilane; methanesulfonic acid; In dichloromethane;

Reference yield:

4‐amino‐N‐(3‐bromo‐4‐fluorophenyl)‐N'‐hydroxy‐1,2,5‐oxadiazole‐3‐carboximidamide → (9H-fluoren-9-yl)methyl N-(2-((4-(4-(3-bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1,2,5-oxadiazol-3-yl)amino)ethyl)sulfamoylcarbamate (1771804-78-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ethyl acetate / 0.33 h / 60 °C

2.1: methanesulfonic acid; triethylsilane / dichloromethane / 0.17 h / 20 °C

2.2: 98 h / 13 - 22 °C

With triethylsilane; methanesulfonic acid; In dichloromethane; ethyl acetate;

upstream raw materials:

9-Fluorenylmethanol

3‐(4‐amino‐1,2,5‐oxadiazol‐3‐yl)‐4‐(3‐bromo‐4‐fluorophenyl)‐1,2,4‐oxadiazol‐5‐one