914471-43-5Relevant articles and documents
2, 3-dioxygenase inhibitor containing substituted amidino structure as well as preparation method and application thereof
-
Paragraph 0019; 0025; 0032-0033, (2020/10/06)
The invention belongs to the field of drug synthesis, and relates to a 1,2,5-oxadiazole compound csubstituted amidino group as shown in a general formula (I) and pharmaceutically acceptable salts thereof, and a preparation method and medical application o
Design, synthesis, and biological evaluation of 1,2,5-oxadiazole-3-carboximidamide derivatives as novel indoleamine-2,3-dioxygenase 1 inhibitors
Song, Xiaohan,Sun, Pu,Wang, Jiang,Guo, Wei,Wang, Yi,Meng, Ling-hua,Liu, Hong
, (2020/01/23)
Indoleamine 2,3-dioxygenase 1 (IDO1) is the enzyme catalyzing the oxidative metabolism of tryptophan, which accounts for cancer immunosuppression in tumor microenvironment. Several compounds targeting IDO1 have been reported and epacadostat shows strong i
DEUTERATED INDOLEAMINE 2,3-DIOXYGENASE INHIBITOR AND APPLICATION THEREOF
-
Paragraph 0167-0169, (2020/12/05)
The present invention belongs to the technical field of medicine, and particularly relates to a compound represented by Formula I, a pharmaceutically acceptable salt thereof, and a stereoisomer thereof, R4, R4′, R5, R