4-(4-Methoxy-phenyl)-thiazol-2-ylamine hydrobromide

Base Information

• Chemical Name: 4-(4-Methoxy-phenyl)-thiazol-2-ylamine hydrobromide
• CAS No.: 111317-60-3
• Molecular Formula: C10H10N2OS.BrH
• Molecular Weight: 287.17600
• UNII: N4FUD49EGK
• Mol file: 111317-60-3.mol

Synonyms:4-(4-Methoxy-phenyl)-thiazol-2-ylamine hydrobromide;111317-60-3;4-(4-methoxyphenyl)thiazol-2-amine hydrobromide;4-(4-methoxyphenyl)-1,3-thiazol-2-amine hydrobromide;4-(4-methoxyphenyl)-1,3-thiazol-2-amine;hydrobromide;4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE;HYDROBROMIDE;N4FUD49EGK;SCHEMBL8355367;DEDRXJNGHFHKSR-UHFFFAOYSA-N;2-THIAZOLAMINE, 4-(4-METHOXYPHENYL)-, MONOHYDROBROMIDE;MFCD01595000;STK071332;AKOS003748466;MCULE-4136812302;4-(4-methoxyphenyl)thiazol-2(3H)-imine hydrobromide;F0807-0605;2-Thiazolamine, 4-(4-methoxyphenyl)-, hydrobromide (1:1)

Chemical Property of 4-(4-Methoxy-phenyl)-thiazol-2-ylamine hydrobromide

Chemical Property:

• PSA: 76.38000
• LogP: 3.94020
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 285.97755
• Heavy Atom Count: 15
• Complexity: 183

Purity/Quality:

4-(4-Methoxy-phenyl)-thiazol-2-ylamine;hydrobromide 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=CSC(=N2)N.Br

Technology Process of 4-(4-Methoxy-phenyl)-thiazol-2-ylamine hydrobromide

There total 1 articles about 4-(4-Methoxy-phenyl)-thiazol-2-ylamine hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

thiourea (17356-08-0) + 2-Bromo-4'-methoxyacetophenone (2632-13-5) → 4-(4-methoxyphenyl)thiazol-2-amine hydrobromide (111317-60-3)

Guidance literature:

In water; for 0.166667h; Sonication;

DOI:10.2174/1570180815666180209153925

Reference yield: 43.0%

4-(4-methoxyphenyl)thiazol-2-amine hydrobromide (111317-60-3) + 3-chlorophenylsulfonyl chloride (2888-06-4) → 3-chloro-N-[4-(4-methoxyphenyl)thiazol-2-yl]benzenesulfonamide

Guidance literature:

With pyridine; at 80 ℃; for 1h;

DOI:10.1039/c3md00226h

Reference yield:

4-(4-methoxyphenyl)thiazol-2-amine hydrobromide (111317-60-3) + 4-((2-ethoxy-2-oxoethyl)amino)benzoic acid (23284-85-7) → N-(4-(4-methoxyphenyl)thiazol-2-yl)-4-((2-morpholino-2-oxoethyl)amino)benzamide

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / acetonitrile / 48 h / 75 °C

1.2: 1 h / 20 °C

2.1: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C

With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

thiourea

2-Bromo-4'-methoxyacetophenone