hydrobromide

Base Information

• Chemical Name: hydrobromide
• CAS No.: 111317-60-3
• Molecular Formula: C10H10N2OS.BrH
• Molecular Weight: 287.17600
• Mol file: 111317-60-3.mol

Synonyms:

Chemical Property of hydrobromide

Chemical Property:

• PSA: 76.38000
• LogP: 3.94020

Purity/Quality:

4-(4-Methoxy-phenyl)-thiazol-2-ylamine;hydrobromide 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of hydrobromide

There total 1 articles about hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

thiourea (17356-08-0) + 2-Bromo-4'-methoxyacetophenone (2632-13-5) → 4-(4-methoxyphenyl)thiazol-2-amine hydrobromide (111317-60-3)

Guidance literature:

In water; for 0.166667h; Sonication;

DOI:10.2174/1570180815666180209153925

Reference yield: 43.0%

4-(4-methoxyphenyl)thiazol-2-amine hydrobromide (111317-60-3) + 3-chlorophenylsulfonyl chloride (2888-06-4) → 3-chloro-N-[4-(4-methoxyphenyl)thiazol-2-yl]benzenesulfonamide

Guidance literature:

With pyridine; at 80 ℃; for 1h;

DOI:10.1039/c3md00226h

Reference yield:

4-(4-methoxyphenyl)thiazol-2-amine hydrobromide (111317-60-3) + 4-((2-ethoxy-2-oxoethyl)amino)benzoic acid (23284-85-7) → N-(4-(4-methoxyphenyl)thiazol-2-yl)-4-((2-morpholino-2-oxoethyl)amino)benzamide

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / acetonitrile / 48 h / 75 °C

1.2: 1 h / 20 °C

2.1: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C

With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

thiourea

2-Bromo-4'-methoxyacetophenone

Refernces

• 1、 Facchinetti, Victor,de Souza, Marcus V. N.,Nery, Ana C. S.,Calixto, Stephane L.,Granato, Juliana T.,Coimbra, Elaine S.,Louren?o, Maria C. S.,Gomes, Claudia R. B.,Vasconcelos, Thatyana R. A.. "Synthetic aspects and first-time assessment of 2-amino-1,3-selenazoles against Mycobacterium tuberculosis". . p. 1224 - 1229. Retrieved 2018/11/01.