(5S,6R,9R)-6-[(E)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-9-methyl-1-oxa-spiro[4.5]deca-3,7-dien-2-one

Base Information

• Chemical Name: (5S,6R,9R)-6-[(E)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-9-methyl-1-oxa-spiro[4.5]deca-3,7-dien-2-one
• CAS No.: 129144-86-1
• Molecular Formula: C₃₉H₅₆O₆Si₂
• Molecular Weight: 677.041

Synonyms:

Chemical Property of (5S,6R,9R)-6-[(E)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-9-methyl-1-oxa-spiro[4.5]deca-3,7-dien-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5S,6R,9R)-6-[(E)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-9-methyl-1-oxa-spiro[4.5]deca-3,7-dien-2-one

There total 16 articles about (5S,6R,9R)-6-[(E)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-9-methyl-1-oxa-spiro[4.5]deca-3,7-dien-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (2E)-2-(hydroxymethyl)-2-butenoate (28127-64-2) → (5S,6R,9R)-6-[(E)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-9-methyl-1-oxa-spiro[4.5]deca-3,7-dien-2-one (129144-86-1,147058-90-0,147059-01-6)

Guidance literature:

Multi-step reaction with 14 steps

1: 98 percent / imidazole / dimethylformamide / 23 °C

2: 94 percent / DIBAL-H / diethyl ether / -50 - -30 °C

3: 86 percent / MnO₂ / CH₂Cl₂ / 23 °C

4: 90 percent / CH₂Cl₂ / Heating

5: 96 percent / DIBAL-H / diethyl ether / -50 °C

6: 98 percent / MnO₂ / CH₂Cl₂ / 23 °C

7: 89 percent / LiN(TMS)2 / tetrahydrofuran / 0 °C

8: 73 percent / BHT / trichloroethene / 16 h / 135 °C

9: 97 percent / DIBAL-H / CH₂Cl₂ / -78 - -30 °C

10: 89 percent / imidazole / dimethylformamide / 23 °C

11: 1) DMSO, (COCl)2, 2) Et₃N / 1) -78 deg C, CH₂Cl₂

12: K₂CO₃ / 0 °C

13: DMAP, Et₃N / CH₂Cl₂

14: 1) LiN(TMS)2 / 1) THF-HMPA, -78 to 23 deg C, 1 h

With 1H-imidazole; dmap; manganese(IV) oxide; oxalyl dichloride; 2,6-di-tert-butyl-4-methyl-phenol; diisobutylaluminium hydride; potassium carbonate; dimethyl sulfoxide; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; dichloromethane; Trichloroethylene; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)70684-8

Reference yield:

4-{[(tert-butyldiphenylsilyl)oxy]methyl}-2(E),4(Z)-hexadienol (146983-30-4) → (5S,6R,9R)-6-[(E)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-9-methyl-1-oxa-spiro[4.5]deca-3,7-dien-2-one (129144-86-1,147058-90-0,147059-01-6)

Guidance literature:

Multi-step reaction with 9 steps

1: 98 percent / MnO₂ / CH₂Cl₂ / 23 °C

2: 89 percent / LiN(TMS)2 / tetrahydrofuran / 0 °C

3: 73 percent / BHT / trichloroethene / 16 h / 135 °C

4: 97 percent / DIBAL-H / CH₂Cl₂ / -78 - -30 °C

5: 89 percent / imidazole / dimethylformamide / 23 °C

6: 1) DMSO, (COCl)2, 2) Et₃N / 1) -78 deg C, CH₂Cl₂

7: K₂CO₃ / 0 °C

8: DMAP, Et₃N / CH₂Cl₂

9: 1) LiN(TMS)2 / 1) THF-HMPA, -78 to 23 deg C, 1 h

With 1H-imidazole; dmap; manganese(IV) oxide; oxalyl dichloride; 2,6-di-tert-butyl-4-methyl-phenol; diisobutylaluminium hydride; potassium carbonate; dimethyl sulfoxide; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; Trichloroethylene; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)70684-8

Reference yield:

4-{[(tert-butyldiphenylsilyl)oxy]methyl}-2(E),4(Z)-hexadienal (146983-23-5) → (5S,6R,9R)-6-[(E)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-9-methyl-1-oxa-spiro[4.5]deca-3,7-dien-2-one (129144-86-1,147058-90-0,147059-01-6)

Guidance literature:

Multi-step reaction with 8 steps

1: 89 percent / LiN(TMS)2 / tetrahydrofuran / 0 °C

2: 73 percent / BHT / trichloroethene / 16 h / 135 °C

3: 97 percent / DIBAL-H / CH₂Cl₂ / -78 - -30 °C

4: 89 percent / imidazole / dimethylformamide / 23 °C

5: 1) DMSO, (COCl)2, 2) Et₃N / 1) -78 deg C, CH₂Cl₂

6: K₂CO₃ / 0 °C

7: DMAP, Et₃N / CH₂Cl₂

8: 1) LiN(TMS)2 / 1) THF-HMPA, -78 to 23 deg C, 1 h

With 1H-imidazole; dmap; oxalyl dichloride; 2,6-di-tert-butyl-4-methyl-phenol; diisobutylaluminium hydride; potassium carbonate; dimethyl sulfoxide; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; Trichloroethylene; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)70684-8

upstream raw materials:

(1S,2R,5R)-1-Acetoxy-2-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-methyl-cyclohex-3-enecarboxylic acid methyl ester

chloromethyl methyl ether

methyl (2E)-2-(hydroxymethyl)-2-butenoate

2-<<(tert-butyldiphenylsilyl)oxy>methyl>-2(Z)-butenol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 129144-86-1 (5S,6R,9R)-6-[(E)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propenyl]-8-(tert-butyl-diphenyl-silanyloxymethyl)-4-methoxymethoxy-9-methyl-1-oxa-spiro[4.5]deca-3,7-dien-2-one

Send

Send

Metric Ton KG G Pound L ML

Send

Send