cyclobutyl 2-[2-[2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluorophenoxy]phenoxy]-2-methoxyacetate

Base Information

Chemical Name:cyclobutyl 2-[2-[2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluorophenoxy]phenoxy]-2-methoxyacetate
CAS No.:1344992-36-4
Molecular Formula:C₂₅H₂₁ClF₄N₂O₇
Molecular Weight:572.898
Hs Code.:

cyclobutyl 2-[2-[2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluorophenoxy]phenoxy]-2-methoxyacetate

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Chemical Property of cyclobutyl 2-[2-[2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluorophenoxy]phenoxy]-2-methoxyacetate

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Technology Process of cyclobutyl 2-[2-[2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluorophenoxy]phenoxy]-2-methoxyacetate

There total 8 articles about cyclobutyl 2-[2-[2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluorophenoxy]phenoxy]-2-methoxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 497866-29-2
3-[2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl-1,2,3,6-tetrahydropyrimidin-1-yl)phenoxy]-2-methoxypyridine

: 1344992-36-4
cyclobutyl 2-[2-[2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluorophenoxy]phenoxy]-2-methoxyacetate

Guidance literature:: Multi-step reaction with 5 steps

1: boron tribromide / dichloromethane / 48 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide; acetonitrile / 20 - 60 °C / Inert atmosphere

3: indium(III) chloride / 9 h / 75 - 82 °C

4: sodium 4-methylbenzenesulfinate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; methanol / 6 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; 2-chloro-1-methyl-pyridinium iodide / tetrahydrofuran / 21 h / 20 °C

With indium(III) chloride; 2-chloro-1-methyl-pyridinium iodide; boron tribromide; potassium carbonate; sodium 4-methylbenzenesulfinate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 497866-09-8
3-(4-chloro-2-fluoro-5-((2-oxo-1,2-dihydropyridin-3-yl)oxy)phenyl)-1-methyl-6-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione

: 1344992-36-4
cyclobutyl 2-[2-[2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluorophenoxy]phenoxy]-2-methoxyacetate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide; acetonitrile / 20 - 60 °C / Inert atmosphere

2: indium(III) chloride / 9 h / 75 - 82 °C

3: sodium 4-methylbenzenesulfinate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; methanol / 6 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; 2-chloro-1-methyl-pyridinium iodide / tetrahydrofuran / 21 h / 20 °C

With indium(III) chloride; 2-chloro-1-methyl-pyridinium iodide; potassium carbonate; sodium 4-methylbenzenesulfinate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 497866-25-8
3-[4-fluoro-2-nitro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl-1,2,3,6-tetrahydropyrimidin-1-yl)phenoxy]-2-methoxypyridine

: 1344992-36-4
cyclobutyl 2-[2-[2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluorophenoxy]phenoxy]-2-methoxyacetate

Guidance literature:: Multi-step reaction with 7 steps

1: acetic acid; iron / water / 2 h / 35 °C

2: copper(l) chloride; copper dichloride; isopentyl nitrite / acetonitrile / 1 h / 20 °C

3: boron tribromide / dichloromethane / 48 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide; acetonitrile / 20 - 60 °C / Inert atmosphere

5: indium(III) chloride / 9 h / 75 - 82 °C

6: sodium 4-methylbenzenesulfinate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; methanol / 6 h / 20 °C

7: N-ethyl-N,N-diisopropylamine; 2-chloro-1-methyl-pyridinium iodide / tetrahydrofuran / 21 h / 20 °C

With indium(III) chloride; 2-chloro-1-methyl-pyridinium iodide; boron tribromide; iron; potassium carbonate; acetic acid; sodium 4-methylbenzenesulfinate; N-ethyl-N,N-diisopropylamine; copper(l) chloride; copper dichloride; isopentyl nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;