3-[4-fluoro-2-nitro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl-1,2,3,6-tetrahydropyrimidin-1-yl)phenoxy]-2-methoxypyridine

Base Information

Chemical Name:3-[4-fluoro-2-nitro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl-1,2,3,6-tetrahydropyrimidin-1-yl)phenoxy]-2-methoxypyridine
CAS No.:497866-25-8
Molecular Formula:C₁₈H₁₂F₄N₄O₆
Molecular Weight:456.31
Hs Code.:

Synonyms:3-[4-fluoro-2-nitro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl-1,2,3,6-tetrahydropyrimidin-1-yl)phenoxy]-2-methoxypyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[4-fluoro-2-nitro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl-1,2,3,6-tetrahydropyrimidin-1-yl)phenoxy]-2-methoxypyridine

Chemical Property:

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Technology Process of 3-[4-fluoro-2-nitro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl-1,2,3,6-tetrahydropyrimidin-1-yl)phenoxy]-2-methoxypyridine

There total 1 articles about 3-[4-fluoro-2-nitro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl-1,2,3,6-tetrahydropyrimidin-1-yl)phenoxy]-2-methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13472-83-8
2-methoxy-3-hydroxypyridine

: 344420-23-1
2,5-difluoro-4-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-1,2,3,6-tetrahydropyrimidin-1-yl]nitrobenzene

: 497866-25-8
3-[4-fluoro-2-nitro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl-1,2,3,6-tetrahydropyrimidin-1-yl)phenoxy]-2-methoxypyridine

Guidance literature:: With potassium carbonate; In DMF (N,N-dimethyl-formamide); for 6h; Heating / reflux;

Reference yield:

: 497866-25-8
3-[4-fluoro-2-nitro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl-1,2,3,6-tetrahydropyrimidin-1-yl)phenoxy]-2-methoxypyridine

: 497866-27-0
3-[2-amino-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl-1,2,3,6-tetrahydropyrimidin-1-yl)phenoxy]-2-methoxypyridine

Guidance literature:: With iron; acetic acid; In water; ethyl acetate; at 80 ℃; for 0.25h;

Reference yield:

: 497866-25-8
3-[4-fluoro-2-nitro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl-1,2,3,6-tetrahydropyrimidin-1-yl)phenoxy]-2-methoxypyridine

: 1344992-35-3
2-[2-[2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluorophenoxy]phenoxy]-2-methoxyacetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: acetic acid; iron / water / 2 h / 35 °C

2: copper(l) chloride; copper dichloride; isopentyl nitrite / acetonitrile / 1 h / 20 °C

3: boron tribromide / dichloromethane / 48 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide; acetonitrile / 20 - 60 °C / Inert atmosphere

5: indium(III) chloride / 9 h / 75 - 82 °C

6: sodium 4-methylbenzenesulfinate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; methanol / 6 h / 20 °C

With indium(III) chloride; boron tribromide; iron; potassium carbonate; acetic acid; sodium 4-methylbenzenesulfinate; copper(l) chloride; copper dichloride; isopentyl nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;