4-[2-(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]-3-oxobutanoic Acid Methyl Ester

Base Information

Chemical Name:4-[2-(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]-3-oxobutanoic Acid Methyl Ester
CAS No.:111429-90-4
Molecular Formula:C15H15NO6
Molecular Weight:305.28300
Hs Code.:
Mol file:111429-90-4.mol

Synonyms:.methyl 4-(2-(phthalimido)ethoxy)acetoacetate;4-[2-(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]-3-oxobutanoic Acid Methyl Ester;.methyl-4-[2-(phthalimido)ethoxy]acetoacetate;.methyl 4-((2'-hydroxyethyl)phthalimide)acetoacetate;4-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-3-oxo-butyric acid methyl ester;

Suppliers and Price of 4-[2-(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]-3-oxobutanoic Acid Methyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-[2-(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]-3-oxobutanoicAcidMethylEster
50mg
$ 195.00

Medical Isotopes, Inc.
4-[2-(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]-3-oxobutanoicAcidMethylEster
50 mg
$ 675.00

Medical Isotopes, Inc.
4-[2-(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]-3-oxobutanoicAcidMethylEster
500 mg
$ 2400.00

aablocks
Methyl4-(2-(1,3-dioxoisoindolin-2-yl)ethoxy)-3-oxobutanoate 95%
1g
$ 1976.00

Total 6 raw suppliers

Chemical Property of 4-[2-(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]-3-oxobutanoic Acid Methyl Ester

Chemical Property:

Boiling Point:470.2±30.0 °C(Predicted)
PKA:9.81±0.46(Predicted)
PSA：89.98000
Density:1.329±0.06 g/cm3(Predicted)
LogP:0.36930
Solubility.:DCM, Ethyl Acetate, Methanol

Purity/Quality:

97% ^*data from raw suppliers

4-[2-(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]-3-oxobutanoicAcidMethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 4-[2-(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]-3-oxobutanoic Acid Methyl Ester is an intermediate in the synthesis of Amlodipine Besilate (A633500) related compounds.

Technology Process of 4-[2-(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]-3-oxobutanoic Acid Methyl Ester

There total 2 articles about 4-[2-(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]-3-oxobutanoic Acid Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.1%

: 3891-07-4
N-(2-Hydroxyethyl)phthalimide

: C₁₃H₁₆O₆S

: 111429-90-4
methyl 4-[2-(phthalimido)-ethoxy]acetoacetate

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; at 20 ℃; for 3h; Reagent/catalyst; Reflux;

Reference yield: 55.0%

: 3891-07-4
N-(2-Hydroxyethyl)phthalimide

: 32807-28-6,935731-94-5
Methyl 4-chloroacetoacetate

: 111429-90-4
methyl 4-[2-(phthalimido)-ethoxy]acetoacetate

Guidance literature:: N-(2-Hydroxyethyl)phthalimide; With sodium hydride; In tetrahydrofuran; at -10 ℃; for 0.583333h;

Methyl 4-chloroacetoacetate; In tetrahydrofuran; at -10 - 20 ℃; for 18h;