9H-fluoren-9-ylmethyl N-[(1S)-2-chloro-2-oxo-1-phenylethyl]carbamate

Base Information

Chemical Name:9H-fluoren-9-ylmethyl N-[(1S)-2-chloro-2-oxo-1-phenylethyl]carbamate
CAS No.:111524-96-0
Molecular Formula:C23H18ClNO3
Molecular Weight:391.854
Hs Code.:
DSSTox Substance ID:DTXSID401159981
Nikkaji Number:J1.896.897E
Mol file:111524-96-0.mol

Synonyms:DTXSID401159981;111524-96-0;9H-fluoren-9-ylmethyl N-[(1S)-2-chloro-2-oxo-1-phenylethyl]carbamate

Suppliers and Price of 9H-fluoren-9-ylmethyl N-[(1S)-2-chloro-2-oxo-1-phenylethyl]carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 9H-fluoren-9-ylmethyl N-[(1S)-2-chloro-2-oxo-1-phenylethyl]carbamate

Chemical Property:

XLogP3:5.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:391.0975211
Heavy Atom Count:28
Complexity:540

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)C(C(=O)Cl)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24
Isomeric SMILES:C1=CC=C(C=C1)[C@@H](C(=O)Cl)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Technology Process of 9H-fluoren-9-ylmethyl N-[(1S)-2-chloro-2-oxo-1-phenylethyl]carbamate

There total 1 articles about 9H-fluoren-9-ylmethyl N-[(1S)-2-chloro-2-oxo-1-phenylethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 102410-65-1,163883-97-4
Fmoc-Phg-OH

: 111524-96-0
Fmoc-L-Phg-Cl

Guidance literature:: With thionyl chloride; In dichloromethane; for 24h; Ambient temperature;

Reference yield: 97.0%

: 2577-90-4
methyl (2S)-2-amino-3-phenylpropanoate

: 111524-96-0
Fmoc-L-Phg-Cl

: 111524-86-8
methyl 2-(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-phenylacetamido)-3-phenylpropanoate

Guidance literature:: With dicyclohexylamine salt of 1-hydroxy-7-aza benzotriazole; In tetrahydrofuran; at 20 ℃;

Reference yield: 93.0%

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 111524-96-0
Fmoc-L-Phg-Cl

: 111524-86-8
methyl 2-(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-phenylacetamido)-3-phenylpropanoate

Guidance literature:: methyl (2S)-2-amino-3-phenylpropanoate hydrochloride; With chloro-trimethyl-silane; zinc; In chloroform; for 0.25h;

Fmoc-L-Phg-Cl; In chloroform; at 20 ℃; for 0.166667h;
DOI:10.1016/j.tetlet.2005.04.007