ETHYL 1-(PHENYLSULFONYL)-4-PIPERIDINECARBOXYLATE

Base Information

• Chemical Name: ETHYL 1-(PHENYLSULFONYL)-4-PIPERIDINECARBOXYLATE
• CAS No.: 111627-26-0
• Molecular Formula: C14H19NO4S
• Molecular Weight: 297.375
• Hs Code.: 2935009090
• Mol file: 111627-26-0.mol

Synonyms:.ethyl 1-(phenylsulfonyl)piperidin-4-carboxylate;.1-Benzolsulfonyl-piperidin-4-carbonsaeure-aethylester;1-BENZENESULFONYL-PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER;ETHYL 1-(BENZENESULFONYL)PIPERIDINE-4-CARBOXYLATE;ethyl 1-(phenylsulfonyl)piperidine-4-carboxylate;.1-(phenylsulfonyl)-4-piperidinecarboxylic acid,ethyl ester;.1-benzenesulfonyl-piperidine-4-carboxylic acid ethyl ester;

Chemical Property of ETHYL 1-(PHENYLSULFONYL)-4-PIPERIDINECARBOXYLATE

Chemical Property:

• Melting Point: 82.5 °C
• Boiling Point: 422.3±55.0 °C(Predicted)
• PKA: -5.68±0.40(Predicted)
• PSA: 72.06000
• Density: 1.244±0.06 g/cm3(Predicted)
• LogP: 2.66910

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl1-(Phenylsulfonyl)piperidine-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 1-(PHENYLSULFONYL)-4-PIPERIDINECARBOXYLATE

There total 11 articles about ETHYL 1-(PHENYLSULFONYL)-4-PIPERIDINECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-carbethoxypiperidine (1126-09-6) + benzenesulfonyl chloride (98-09-9) → 1-(phenylsulfonyl)-4-piperidinecarboxylic acid ethyl ester (111627-26-0)

Guidance literature:

With sodium carbonate; In water; at 0 - 30 ℃; pH=9;

DOI:10.3906/kim-1303-89

Reference yield: 56.0%

4-carbethoxypiperidine (1126-09-6) + phenylboronic acid (98-80-6) → 1-(phenylsulfonyl)-4-piperidinecarboxylic acid ethyl ester (111627-26-0)

Guidance literature:

With 4,4'-Dimethoxy-2,2'-bipyridin; 1,4-diazabicyclo [2.2.2] octane-1,4-diium-1,4-disulfinate; copper(II) bis(trifluoromethanesulfonate); caesium carbonate; dimethyl sulfoxide; at 130 ℃; for 16h; Inert atmosphere; Sealed tube;

DOI:10.1021/jacs.8b04532

Reference yield:

4-carbethoxypiperidine (1126-09-6) → 1-(phenylsulfonyl)-4-piperidinecarboxylic acid ethyl ester (111627-26-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃;

DOI:10.1016/j.tetlet.2006.11.072

upstream raw materials:

4-benzenesulfonylisonipecotic acid

4-carbethoxypiperidine

benzenesulfonyl chloride

N,N-bis[2-[(phenylsulfonyl)oxy]ethyl]-benzenesulfonamide

Downstream raw materials:

α,α-bis(4-fluorophenyl)-1-(phenylsulfonyl)-4-piperidinemethanol

4-benzenesulfonylisonipecotic acid

N',1-bis(phenylsulfonyl)piperidine-4-carbohydrazide

Refernces

• 1、 Chen, Yiding,Murray, Philip R. D.,Davies, Alyn T.,Willis, Michael C.. "Direct Copper-Catalyzed Three-Component Synthesis of Sulfonamides". supporting information. p. 8781 - 8787. Retrieved 2018/07/29.
• 2、 Aziz-Ur-Rehman,Khalid, Hira,Abbasi, Muhammad Athar,Gul, Samreen,Khan, Khalid Mohammed,Ahmad, Irshad,Arshad, Shafia. "Synthesis of potent antibacterial agents derived from 5-[1-(phenylsulfonyl) piperidin-4-yl]-1,3,4-Oxadiazol-2-thiol". . p. 131 - 139. Retrieved 2014/05/06.