(Z)-(3RS,4RS)-methyl 3--4-<(diethoxyphosphinyl)methyl>pyrazoline-3-carboxylate

Base Information

Chemical Name:(Z)-(3RS,4RS)-methyl 3--4-<(diethoxyphosphinyl)methyl>pyrazoline-3-carboxylate
CAS No.:133753-38-5
Molecular Formula:C₁₈H₂₆N₃O₇P
Molecular Weight:427.394
Hs Code.:

(Z)-(3RS,4RS)-methyl 3-<N-(benzyloxycarbonyl)amino>-4-<(diethoxyphosphinyl)methyl>pyrazoline-3-carboxylate

Synonyms:

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Chemical Property of (Z)-(3RS,4RS)-methyl 3--4-<(diethoxyphosphinyl)methyl>pyrazoline-3-carboxylate

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Technology Process of (Z)-(3RS,4RS)-methyl 3--4-<(diethoxyphosphinyl)methyl>pyrazoline-3-carboxylate

There total 7 articles about (Z)-(3RS,4RS)-methyl 3--4-<(diethoxyphosphinyl)methyl>pyrazoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 133753-37-4
(E)-methyl 2--4-(diethoxyphosphinyl)-2-butenoate

: 133753-38-5,133753-39-6
(E)-(3RS,4SR)-methyl 3--4-<(diethoxyphosphinyl)methyl>pyrazoline-3-carboxylate

Guidance literature:: In diethyl ether; for 72h; Ambient temperature;
DOI:10.1021/jm00109a023

Reference yield: 67.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 133753-36-3
(Z)-methyl 2--4-(diethoxyphosphinyl)-2-butenoate

: 133753-38-5,133753-39-6
(Z)-(3RS,4RS)-methyl 3--4-<(diethoxyphosphinyl)methyl>pyrazoline-3-carboxylate

Guidance literature:: In diethyl ether; for 72h; Ambient temperature;
DOI:10.1021/jm00109a023

Reference yield:

: 1606-75-3
(2-oxoethyl)phosphonic acid diethyl ester

: 133753-38-5,133753-39-6
(E)-(3RS,4SR)-methyl 3--4-<(diethoxyphosphinyl)methyl>pyrazoline-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) potassium tert-butoxide / 1.) CH₂Cl₂, -78 deg C, 20 min, 2.) CH₂Cl₂, RT, 2 h

2: 88 percent / diethyl ether / 72 h / Ambient temperature

With potassium tert-butylate; In diethyl ether;
DOI:10.1021/jm00109a023