1-(3-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazole 2'-<2,5-dichlorophenyl pyridinium phosphate>

Base Information

Chemical Name:1-(3-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazole 2'-<2,5-dichlorophenyl pyridinium phosphate>
CAS No.:137016-67-2
Molecular Formula:C₅H₅N*C₄₄H₄₅Cl₄N₂O₈PSi
Molecular Weight:1009.82
Hs Code.:

1-(3-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazole 2'-<2,5-dichlorophenyl pyridinium phosphate>

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Chemical Property of 1-(3-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazole 2'-<2,5-dichlorophenyl pyridinium phosphate>

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Technology Process of 1-(3-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazole 2'-<2,5-dichlorophenyl pyridinium phosphate>

There total 7 articles about 1-(3-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazole 2'-<2,5-dichlorophenyl pyridinium phosphate> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6478-73-5
5,6-dichlorobenzimidazole

: 137016-67-2
1-(3-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazole 2'-<2,5-dichlorophenyl pyridinium phosphate>

Guidance literature:: Multi-step reaction with 5 steps

1: 51 percent / p-TsOH / 1 h / 170 - 180 °C / 20 Torr

2: NaOMe / methanol

3: 87 percent / pyridine / Ambient temperature

4: 35 percent / pyridine / 18 h / Ambient temperature

With pyridine; sodium methylate; toluene-4-sulfonic acid; In methanol;
DOI:10.1016/0008-6215(92)84178-U

Reference yield:

: 6974-32-9
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

: 137016-67-2
1-(3-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazole 2'-<2,5-dichlorophenyl pyridinium phosphate>

Guidance literature:: Multi-step reaction with 5 steps

1: 51 percent / p-TsOH / 1 h / 170 - 180 °C / 20 Torr

2: NaOMe / methanol

3: 87 percent / pyridine / Ambient temperature

4: 35 percent / pyridine / 18 h / Ambient temperature

With pyridine; sodium methylate; toluene-4-sulfonic acid; In methanol;
DOI:10.1016/0008-6215(92)84178-U

Reference yield:

: 108126-17-6,443678-71-5
(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(5,6-dichloro-1H-benzo[d]imidazol-1-yl)tetrahydrofuran-3,4-diyl diacetate

: 137016-67-2
1-(3-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazole 2'-<2,5-dichlorophenyl pyridinium phosphate>

Guidance literature:: Multi-step reaction with 4 steps

1: NaOMe / methanol

2: 87 percent / pyridine / Ambient temperature

3: 35 percent / pyridine / 18 h / Ambient temperature

With pyridine; sodium methylate; In methanol;
DOI:10.1016/0008-6215(92)84178-U