(R)-3-Benzenesulfonyl-6-[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-3-(tetrahydro-pyran-2-yloxy)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-1,1,1-trifluoro-2-methyl-heptan-2-ol

Base Information

Chemical Name:(R)-3-Benzenesulfonyl-6-[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-3-(tetrahydro-pyran-2-yloxy)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-1,1,1-trifluoro-2-methyl-heptan-2-ol
CAS No.:81239-80-7
Molecular Formula:C₃₈H₅₅F₃O₅S
Molecular Weight:680.913
Hs Code.:

(R)-3-Benzenesulfonyl-6-[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-3-(tetrahydro-pyran-2-yloxy)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-1,1,1-trifluoro-2-methyl-heptan-2-ol

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Chemical Property of (R)-3-Benzenesulfonyl-6-[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-3-(tetrahydro-pyran-2-yloxy)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-1,1,1-trifluoro-2-methyl-heptan-2-ol

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Technology Process of (R)-3-Benzenesulfonyl-6-[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-3-(tetrahydro-pyran-2-yloxy)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-1,1,1-trifluoro-2-methyl-heptan-2-ol

There total 1 articles about (R)-3-Benzenesulfonyl-6-[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-3-(tetrahydro-pyran-2-yloxy)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-1,1,1-trifluoro-2-methyl-heptan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 421-50-1
1,1,1-trifluoro-2-propanone

: 75303-40-1
24-phenylsulphonylchol-5-en-3β-ol 3-tetrahydropyranyl ether

: 81239-80-7
(R)-3-Benzenesulfonyl-6-[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-3-(tetrahydro-pyran-2-yloxy)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-1,1,1-trifluoro-2-methyl-heptan-2-ol

Guidance literature:: In tetrahydrofuran; at -78 ℃; for 0.25h; Yield given;
DOI:10.1016/S0040-4039(01)82942-7

Reference yield:

: 81239-80-7
(R)-3-Benzenesulfonyl-6-[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-3-(tetrahydro-pyran-2-yloxy)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-1,1,1-trifluoro-2-methyl-heptan-2-ol

: 81245-07-0
26,26,26-trifluoro-25-hydroxyvitamin D₃

Guidance literature:: Multi-step reaction with 6 steps

1: 14 percent / 4percent Na-Hg, Na₂HPO₄ / tetrahydrofuran; methanol / 1.5 h / Ambient temperature

2: 1.) p-TsOH / 1.) CH₂Cl₂, MeOH, room temp., 2h 2.)Pyridine, 15 h, room temp.

3: 1.) NBS 2.) s-collidine / 1.) CCl₄, reflux, 15 min. 2.) xylene, reflux, 10 min.

4: p- TsOH / acetone / 12 h

5: 18 percent / ethanol; benzene / 1 h / Heating; Irradiation

6: 5percent KOH / methanol; tetrahydrofuran / 16 h / Ambient temperature

With 2,4,6-trimethyl-pyridine; potassium hydroxide; disodium hydrogenphosphate; N-Bromosuccinimide; sodium amalgam; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; ethanol; acetone; benzene;
DOI:10.1016/S0040-4039(01)82942-7

Reference yield:

: 81239-80-7
(R)-3-Benzenesulfonyl-6-[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-3-(tetrahydro-pyran-2-yloxy)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-1,1,1-trifluoro-2-methyl-heptan-2-ol

: 77754-85-9
Acetic acid (S)-4-methylene-3-[2-[(1R,3aS,7aR)-7a-methyl-1-((R)-6,6,6-trifluoro-5-hydroxy-1,5-dimethyl-hexyl)-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-cyclohexyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 14 percent / 4percent Na-Hg, Na₂HPO₄ / tetrahydrofuran; methanol / 1.5 h / Ambient temperature

2: 1.) p-TsOH / 1.) CH₂Cl₂, MeOH, room temp., 2h 2.)Pyridine, 15 h, room temp.

3: 1.) NBS 2.) s-collidine / 1.) CCl₄, reflux, 15 min. 2.) xylene, reflux, 10 min.

4: p- TsOH / acetone / 12 h

5: 18 percent / ethanol; benzene / 1 h / Heating; Irradiation

With 2,4,6-trimethyl-pyridine; disodium hydrogenphosphate; N-Bromosuccinimide; sodium amalgam; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; ethanol; acetone; benzene;
DOI:10.1016/S0040-4039(01)82942-7