2-[2-(trifluoromethyl)phenyl]oxirane

Base Information

• Chemical Name: 2-[2-(trifluoromethyl)phenyl]oxirane
• CAS No.: 111991-15-2
• Molecular Formula: C9H7F3O
• Molecular Weight: 188.149
• Mol file: 111991-15-2.mol

Synonyms:

Chemical Property of 2-[2-(trifluoromethyl)phenyl]oxirane

Chemical Property:

• Boiling Point: 50 °C(Press: 0.06 Torr)
• PSA: 12.53000
• Density: 1.325±0.06 g/cm3(Predicted)
• LogP: 2.77670

Purity/Quality:

99% ^*data from raw suppliers

2-[2-(Trifluoromethyl)phenyl]oxirane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[2-(trifluoromethyl)phenyl]oxirane

There total 2 articles about 2-[2-(trifluoromethyl)phenyl]oxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-Trifluoromethylbenzaldehyde (447-61-0) + trimethylsulphonium iodide (2181-42-2) → (+/-)-2-((2-trifluoromethyl)phenyl)oxirane (111991-15-2)

Guidance literature:

With sodium hydride; In dimethyl sulfoxide; at 20 ℃;

DOI:10.1002/adsc.200700085

Reference yield:

o-(trifluoromethyl)styrene (395-45-9) → (+/-)-2-((2-trifluoromethyl)phenyl)oxirane (111991-15-2)

Guidance literature:

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/anie.201708519

Reference yield: 100.0%

(+/-)-2-((2-trifluoromethyl)phenyl)oxirane (111991-15-2) → 1-(2-trifluoromethyl-phenyl)-ethane-1,2-diol

Guidance literature:

With sulfuric acid; In tetrahydrofuran; water;

DOI:10.1002/adsc.200606061

upstream raw materials:

2-Trifluoromethylbenzaldehyde

trimethylsulphonium iodide

o-(trifluoromethyl)styrene

Downstream raw materials:

2-(2-trifluoromethyl-phenyl)-4-trimethylsilanyl-but-3-yn-1-ol

2-(2-trifluoromethyl-phenyl)-but-3-yn-1-ol

tert-butyl-dimethyl-[2-(2-trifluoromethyl-phenyl)-but-3-ynyloxy]-silane

(D)-ortho-trifluoromethylstyrene oxide

Refernces

• 1、 Iovan, Diana A.,Wilding, Matthew J. T.,Baek, Yunjung,Hennessy, Elisabeth T.,Betley, Theodore A.. "Diastereoselective C?H Bond Amination for Disubstituted Pyrrolidines". supporting information. p. 15599 - 15602. Retrieved 2017/11/16.
• 2、 Deregnaucourt, Justine,Archelas, Alain,Barbirato, Fabien,Paris, Jean-Marc,Furstoss, Roland. "Enzymatic transformations 63. High-concentration two liquid-liquid phase Aspergillus niger Epoxide hydrolase-catalysed resolution: Application to trifluoromethyl-substituted aromatic epoxides". . p. 1405 - 1417. Retrieved 2008/03/28.