Oxirane, [4-(trifluoromethoxy)phenyl]-

Base Information

• Chemical Name: Oxirane, [4-(trifluoromethoxy)phenyl]-
• CAS No.: 111991-17-4
• Molecular Formula: C9H7F3O2
• Molecular Weight: 204.149
• Mol file: 111991-17-4.mol

Synonyms:

Chemical Property of Oxirane, [4-(trifluoromethoxy)phenyl]-

Chemical Property:

Purity/Quality:

NLT 98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Oxirane, [4-(trifluoromethoxy)phenyl]-

There total 3 articles about Oxirane, [4-(trifluoromethoxy)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

p-trifluoromethoxybenzaldehyde (659-28-9) + trimethylsulphonium iodide (2181-42-2) → 2-(4-trifluoromethoxy-phenyl)-oxirane (111991-17-4)

Guidance literature:

With sodium hydride; In dimethyl sulfoxide; at 20 ℃;

DOI:10.1002/adsc.200700085

Reference yield: 45.0%

p-trifluoromethoxybenzaldehyde (659-28-9) + trimethylsulfoxonium iodide (1774-47-6) → 2-(4-trifluoromethoxy-phenyl)-oxirane (111991-17-4)

Guidance literature:

With sodium hydride; In tetrahydrofuran; dimethyl sulfoxide; at 20 ℃; for 1h;

DOI:10.1021/acs.jmedchem.7b00807

Reference yield:

4-ethenylphenyl trifluoromethyl ether (1736-08-9) → 2-(4-trifluoromethoxy-phenyl)-oxirane (111991-17-4)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In chloroform; at 10 - 35 ℃; for 2h;

upstream raw materials:

p-trifluoromethoxybenzaldehyde

trimethylsulphonium iodide

trimethylsulfoxonium iodide

4-ethenylphenyl trifluoromethyl ether

Downstream raw materials:

2-((S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-ylamino)-2-(4-trifluoromethoxyphenyl)-ethanol

2-hydroxy-1-(4-(trifluoromethoxy)phenyl)ethan-1-one

2-(4-methoxybenzyloxy)-1-(4-(trifluoromethoxy)phenyl)ethanone

2-(4-methoxybenzyloxy)-1-(4-trifluoromethoxyphenyl)-ethanol

Refernces

• 1、 -. "HETEROCYCLIC COMPOUND". Paragraph 1077; 1078. . Retrieved 2016/06/28.
• 2、 Deregnaucourt, Justine,Archelas, Alain,Barbirato, Fabien,Paris, Jean-Marc,Furstoss, Roland. "Enzymatic transformations 63. High-concentration two liquid-liquid phase Aspergillus niger Epoxide hydrolase-catalysed resolution: Application to trifluoromethyl-substituted aromatic epoxides". . p. 1405 - 1417. Retrieved 2008/03/28.