N-4-ethoxyphenyl-DL-mandelamide

Base Information

• Chemical Name: N-4-ethoxyphenyl-DL-mandelamide
• CAS No.: 169040-76-0
• Molecular Formula: C₁₆H₁₇NO₃
• Molecular Weight: 271.316
• DSSTox Substance ID: DTXSID401258218
• Nikkaji Number: J86.097B
• Mol file: 169040-76-0.mol

Synonyms:SCHEMBL7472046;N-4-ethoxyphenyl-DL-mandelamide;LCECFTBDXUVLGA-UHFFFAOYSA-N;DTXSID401258218;169040-76-0;N-(4-Ethoxyphenyl)-I+/--hydroxybenzeneacetamide

Chemical Property of N-4-ethoxyphenyl-DL-mandelamide

Chemical Property:

• XLogP3: 2.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 271.12084340
• Heavy Atom Count: 20
• Complexity: 294

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC1=CC=C(C=C1)NC(=O)C(C2=CC=CC=C2)O

Technology Process of N-4-ethoxyphenyl-DL-mandelamide

There total 3 articles about N-4-ethoxyphenyl-DL-mandelamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+)(Ξ)-((S)-2-methyl-butyryloxy)-phenyl-acetic acid p-phenetidide → mandelic acid-p-phenetidide (169040-76-0)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/ja01191a051

Reference yield:

p-ethoxy phenyl isonitrile (134420-06-7) → mandelic acid-p-phenetidide (169040-76-0)

Guidance literature:

Multi-step reaction with 2 steps

2: ethanolic NaOH-solution

With sodium hydroxide;

DOI:10.1021/ja01191a051

Reference yield:

benzaldehyde (100-52-7) → mandelic acid-p-phenetidide (169040-76-0)

Guidance literature:

Multi-step reaction with 2 steps

2: ethanolic NaOH-solution

With sodium hydroxide;

DOI:10.1021/ja01191a051

upstream raw materials:

p-ethoxy phenyl isonitrile

benzaldehyde

Downstream raw materials:

3-Amino-5-chloro-3-(2-chlorophenyl)-1,3-di-hydroindol-2-one

5-Ethoxy-1,3-dihydro-3-phenylindol-2-one