Pyrazolo(1,5-a)pyrimidin-7-amine, N-butyl-3-(2,4-dichlorophenyl)-N-ethyl-2,5-dimethyl-

Base Information

Chemical Name:Pyrazolo(1,5-a)pyrimidin-7-amine, N-butyl-3-(2,4-dichlorophenyl)-N-ethyl-2,5-dimethyl-
CAS No.:202579-59-7
Molecular Formula:C₂₀H₂₄Cl₂N₄
Molecular Weight:391.343
Hs Code.:
UNII:4U96TT078E
Wikidata:Q27260521
Pharos Ligand ID:T73J97YL59GG
ChEMBL ID:CHEMBL290762

Synonyms:PD-171729;202579-59-7;UNII-4U96TT078E;CHEMBL290762;4U96TT078E;PD 171729;N-butyl-3-(2,4-dichlorophenyl)-N-ethyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amine;Pyrazolo(1,5-a)pyrimidin-7-amine, N-butyl-3-(2,4-dichlorophenyl)-N-ethyl-2,5-dimethyl-;D0C0AS;SCHEMBL16606731;BDBM50071234;Q27260521;Butyl-[3-(2,4-dichloro-phenyl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-ethyl-amine

Suppliers and Price of Pyrazolo(1,5-a)pyrimidin-7-amine, N-butyl-3-(2,4-dichlorophenyl)-N-ethyl-2,5-dimethyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Pyrazolo(1,5-a)pyrimidin-7-amine, N-butyl-3-(2,4-dichlorophenyl)-N-ethyl-2,5-dimethyl-

Chemical Property:

XLogP3:6.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:390.1378022
Heavy Atom Count:26
Complexity:452

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCCCN(CC)C1=CC(=NC2=C(C(=NN12)C)C3=C(C=C(C=C3)Cl)Cl)C

Technology Process of Pyrazolo(1,5-a)pyrimidin-7-amine, N-butyl-3-(2,4-dichlorophenyl)-N-ethyl-2,5-dimethyl-

There total 7 articles about Pyrazolo(1,5-a)pyrimidin-7-amine, N-butyl-3-(2,4-dichlorophenyl)-N-ethyl-2,5-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 13360-63-9
N-ethylbutylamine

: 948553-53-5
7-chloro-3-(2,4-dichlorophenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine

: 202579-59-7
N-butyl-3-(2,4-dichlorophenyl)-N-ethyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; for 2.5h; Reflux; Inert atmosphere;
DOI:10.1016/j.bmc.2015.06.036

Reference yield:

: 214416-40-7
5-amino-4-(2,4-dichlorophenyl)-3-methylpyrazole

: 202579-59-7
N-butyl-3-(2,4-dichlorophenyl)-N-ethyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amine

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / Heating

2: phosphorus oxychloride; N,N-diethylaniline / toluene / Heating

3: Heating

With N,N-diethylaniline; trichlorophosphate; In acetic acid; toluene; 1: Cyclization / 2: Substitution / 3: Substitution;
DOI:10.1016/S0968-0896(99)00271-0

Reference yield:

: 6306-60-1
2,4-Dichlorophenylacetonitrile

: 202579-59-7
N-butyl-3-(2,4-dichlorophenyl)-N-ethyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amine

Guidance literature:: Multi-step reaction with 5 steps

1: sodium / Heating

2: hydrazine monohydrate; acetic acid / toluene / Heating

3: acetic acid / Heating

4: phosphorus oxychloride; N,N-diethylaniline / toluene / Heating

5: Heating

With sodium; hydrazine hydrate; acetic acid; N,N-diethylaniline; trichlorophosphate; In acetic acid; toluene; 1: Condensation / 2: Cyclization / 3: Cyclization / 4: Substitution / 5: Substitution;
DOI:10.1016/S0968-0896(99)00271-0