benzomilfasartan

Base Information

• Chemical Name: benzomilfasartan
• CAS No.: 1265625-22-6
• Molecular Formula: C₃₂H₃₀N₆OS
• Molecular Weight: 546.696
• Mol file: 1265625-22-6.mol

Synonyms:

Chemical Property of benzomilfasartan

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzomilfasartan

There total 3 articles about benzomilfasartan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

C51H44N6OS (1265625-20-4) → benzomilfasartan (1265625-22-6)

Guidance literature:

In methanol; for 17h; Reflux;

DOI:10.1039/c0ob00573h

Reference yield:

2-bromomethylbenzo[b]thiophene (10133-20-7) → benzomilfasartan (1265625-22-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride; lithium bromide / N,N-dimethyl-formamide; mineral oil / 0 °C / Inert atmosphere

1.2: 0 - 20 °C

2.1: methanol / 17 h / Reflux

With sodium hydride; lithium bromide; In methanol; N,N-dimethyl-formamide; mineral oil;

DOI:10.1039/c0ob00573h

Reference yield:

2-Methylbenzothiophene (1195-14-8) → benzomilfasartan (1265625-22-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / α,α,α-trifluorotoluene / 1.5 h / Reflux

2.1: sodium hydride; lithium bromide / N,N-dimethyl-formamide; mineral oil / 0 °C / Inert atmosphere

2.2: 0 - 20 °C

3.1: methanol / 17 h / Reflux

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; lithium bromide; In methanol; α,α,α-trifluorotoluene; N,N-dimethyl-formamide; mineral oil;

DOI:10.1039/c0ob00573h

upstream raw materials:

2-Methylbenzothiophene

C₅₁H₄₄N₆OS

2-bromomethylbenzo[b]thiophene