(E)-3-((1R,3S)-2,2,3-Trimethyl-6-methylene-cyclohexyl)-acrylic acid

Base Information

Chemical Name:(E)-3-((1R,3S)-2,2,3-Trimethyl-6-methylene-cyclohexyl)-acrylic acid
CAS No.:326907-32-8
Molecular Formula:C₁₃H₂₀O₂
Molecular Weight:208.301
Hs Code.:

Synonyms:

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Chemical Property of (E)-3-((1R,3S)-2,2,3-Trimethyl-6-methylene-cyclohexyl)-acrylic acid

Chemical Property:

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Technology Process of (E)-3-((1R,3S)-2,2,3-Trimethyl-6-methylene-cyclohexyl)-acrylic acid

There total 12 articles about (E)-3-((1R,3S)-2,2,3-Trimethyl-6-methylene-cyclohexyl)-acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55695-33-5
(2,2,4-trimethyl-3-cyclohexen-1-yl)methanol

: 326907-32-8
(E)-3-((1R,3S)-2,2,3-Trimethyl-6-methylene-cyclohexyl)-acrylic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: PPL (SIGMA type II) from Porcine pancreas / diisopropyl ether; hexane / 72 h / 20 °C

2.1: 57 percent / PPL (SIGMA type II) from Porcine pancreas / toluene / 48 h / 20 °C / pH 7

3.1: 100 percent / N-methylmorpholine / diethyl ether

4.1: 67 percent / methanesulfonic acid / diethyl ether

5.1: N-bromosuccinimide / CHCl₃ / 17 h / 20 °C

6.1: Zn / 1,2-dimethoxy-ethane / Heating

7.1: 31 percent / H₂ / PtO₂ / methanol / 27 °C

8.1: 100 percent / NaOH; MeOH

9.1: LDA / tetrahydrofuran

10.1: MsCl; pyridine / CH₂Cl₂

10.2: Zn; NaI / dimethylformamide / Heating

With 4-methyl-morpholine; pyridine; methanol; sodium hydroxide; N-Bromosuccinimide; methanesulfonic acid; PPL (SIGMA type II) from Porcine pancreas; hydrogen; methanesulfonyl chloride; zinc; lithium diisopropyl amide; platinum(IV) oxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; hexane; dichloromethane; chloroform; di-isopropyl ether; toluene;
DOI:10.1016/S0957-4166(00)00345-1

Reference yield:

: 127075-63-2
acetic acid-(2,2,4-trimethyl-cyclohex-3-enylmethyl ester)

: 326907-32-8
(E)-3-((1R,3S)-2,2,3-Trimethyl-6-methylene-cyclohexyl)-acrylic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: PPL (SIGMA type II) from Porcine pancreas / toluene / 48 h / 20 °C / pH 7

2.1: 100 percent / N-methylmorpholine / diethyl ether

3.1: 67 percent / methanesulfonic acid / diethyl ether

4.1: N-bromosuccinimide / CHCl₃ / 17 h / 20 °C

5.1: Zn / 1,2-dimethoxy-ethane / Heating

6.1: 31 percent / H₂ / PtO₂ / methanol / 27 °C

7.1: 100 percent / NaOH; MeOH

8.1: LDA / tetrahydrofuran

9.1: MsCl; pyridine / CH₂Cl₂

9.2: Zn; NaI / dimethylformamide / Heating

With 4-methyl-morpholine; pyridine; methanol; sodium hydroxide; N-Bromosuccinimide; methanesulfonic acid; PPL (SIGMA type II) from Porcine pancreas; hydrogen; methanesulfonyl chloride; zinc; lithium diisopropyl amide; platinum(IV) oxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; chloroform; toluene;
DOI:10.1016/S0957-4166(00)00345-1

Reference yield:

: 108448-46-0
(-)-(S)-2,2,4-trimethyl-3-cyclohexene-1-methanol

: 326907-32-8
(E)-3-((1R,3S)-2,2,3-Trimethyl-6-methylene-cyclohexyl)-acrylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: 100 percent / N-methylmorpholine / diethyl ether

2.1: 67 percent / methanesulfonic acid / diethyl ether

3.1: N-bromosuccinimide / CHCl₃ / 17 h / 20 °C

4.1: Zn / 1,2-dimethoxy-ethane / Heating

5.1: 31 percent / H₂ / PtO₂ / methanol / 27 °C

6.1: 100 percent / NaOH; MeOH

7.1: LDA / tetrahydrofuran

8.1: MsCl; pyridine / CH₂Cl₂

8.2: Zn; NaI / dimethylformamide / Heating

With 4-methyl-morpholine; pyridine; methanol; sodium hydroxide; N-Bromosuccinimide; methanesulfonic acid; hydrogen; methanesulfonyl chloride; zinc; lithium diisopropyl amide; platinum(IV) oxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; chloroform;
DOI:10.1016/S0957-4166(00)00345-1