Technology Process of 6-(Benzamido)-7-deaza-9-(2',3'-dideoxy-β-D-glucopyranosyl)purin
There total 8 articles about 6-(Benzamido)-7-deaza-9-(2',3'-dideoxy-β-D-glucopyranosyl)purin which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 82 percent / H2, AcOH / 10percent Pd/C / methanol / 8 h / Ambient temperature
2: Amberlit IRA 400 (OH--Form) / methanol / 2 h / Ambient temperature
3: pyridine / r.t.
4: 0.4M HCl / acetonitrile; H2O / 1.5 h / Heating
5: 1) tris(dimethylamino)phosphine, CCl4 / 1a) THF, -78 deg C, 1 h, 1b) -78 deg C - r.t., 1 h, 2) MeCN, r.t., 45 min
6: 83 percent / NH3 (gas.) / methanol / 20 h / 130 °C
7: 1) pyridine, chlorotrimethylsilane / 1) 0 deg C, 45 min, 2) 0 deg C - r.t., 2 h
With
pyridine; hydrogenchloride; tetrachloromethane; chloro-trimethyl-silane; ammonia; hydrogen; acetic acid; Hexamethylphosphorous triamide;
palladium on activated charcoal; Amberlit IRA 400 (OH--Form);
In
methanol; water; acetonitrile;
DOI:10.1002/hlca.19920750503
- Guidance literature:
-
Multi-step reaction with 6 steps
1: Amberlit IRA 400 (OH--Form) / methanol / 2 h / Ambient temperature
2: pyridine / r.t.
3: 0.4M HCl / acetonitrile; H2O / 1.5 h / Heating
4: 1) tris(dimethylamino)phosphine, CCl4 / 1a) THF, -78 deg C, 1 h, 1b) -78 deg C - r.t., 1 h, 2) MeCN, r.t., 45 min
5: 83 percent / NH3 (gas.) / methanol / 20 h / 130 °C
6: 1) pyridine, chlorotrimethylsilane / 1) 0 deg C, 45 min, 2) 0 deg C - r.t., 2 h
With
pyridine; hydrogenchloride; tetrachloromethane; chloro-trimethyl-silane; ammonia; Hexamethylphosphorous triamide;
Amberlit IRA 400 (OH--Form);
In
methanol; water; acetonitrile;
DOI:10.1002/hlca.19920750503
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 91 percent / BF3*Et2O / toluene / 40 h / 5 deg C - r.t.
2: 82 percent / H2, AcOH / 10percent Pd/C / methanol / 8 h / Ambient temperature
3: Amberlit IRA 400 (OH--Form) / methanol / 2 h / Ambient temperature
4: pyridine / r.t.
5: 0.4M HCl / acetonitrile; H2O / 1.5 h / Heating
6: 1) tris(dimethylamino)phosphine, CCl4 / 1a) THF, -78 deg C, 1 h, 1b) -78 deg C - r.t., 1 h, 2) MeCN, r.t., 45 min
7: 83 percent / NH3 (gas.) / methanol / 20 h / 130 °C
8: 1) pyridine, chlorotrimethylsilane / 1) 0 deg C, 45 min, 2) 0 deg C - r.t., 2 h
With
pyridine; hydrogenchloride; tetrachloromethane; chloro-trimethyl-silane; boron trifluoride diethyl etherate; ammonia; hydrogen; acetic acid; Hexamethylphosphorous triamide;
palladium on activated charcoal; Amberlit IRA 400 (OH--Form);
In
methanol; water; toluene; acetonitrile;
DOI:10.1002/hlca.19920750503
