(9S,12S)-12-(Benzyloxycarbonyl-methyl-amino)-16,17-dichloro-4,5-dimethoxy-10-methyl-11-oxo-2-oxa-10-aza-tricyclo[12.2.2.1^3,7]nonadeca-1⁽¹⁷⁾,3⁽¹⁹⁾,4,6,14⁽¹⁸⁾,15-hexaene-9-carboxylic acid methyl ester

Base Information

• Chemical Name: (9S,12S)-12-(Benzyloxycarbonyl-methyl-amino)-16,17-dichloro-4,5-dimethoxy-10-methyl-11-oxo-2-oxa-10-aza-tricyclo[12.2.2.1^3,7]nonadeca-1⁽¹⁷⁾,3⁽¹⁹⁾,4,6,14⁽¹⁸⁾,15-hexaene-9-carboxylic acid methyl ester
• CAS No.: 172036-73-6
• Molecular Formula: C₃₁H₃₂Cl₂N₂O₈
• Molecular Weight: 631.51

Synonyms:

Chemical Property of (9S,12S)-12-(Benzyloxycarbonyl-methyl-amino)-16,17-dichloro-4,5-dimethoxy-10-methyl-11-oxo-2-oxa-10-aza-tricyclo[12.2.2.1^3,7]nonadeca-1⁽¹⁷⁾,3⁽¹⁹⁾,4,6,14⁽¹⁸⁾,15-hexaene-9-carboxylic acid methyl ester

Chemical Property:

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Safty Information:

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Technology Process of (9S,12S)-12-(Benzyloxycarbonyl-methyl-amino)-16,17-dichloro-4,5-dimethoxy-10-methyl-11-oxo-2-oxa-10-aza-tricyclo[12.2.2.1^3,7]nonadeca-1⁽¹⁷⁾,3⁽¹⁹⁾,4,6,14⁽¹⁸⁾,15-hexaene-9-carboxylic acid methyl ester

There total 9 articles about (9S,12S)-12-(Benzyloxycarbonyl-methyl-amino)-16,17-dichloro-4,5-dimethoxy-10-methyl-11-oxo-2-oxa-10-aza-tricyclo[12.2.2.1^3,7]nonadeca-1⁽¹⁷⁾,3⁽¹⁹⁾,4,6,14⁽¹⁸⁾,15-hexaene-9-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.2%

diazomethane (186581-53-3,908094-01-9,334-88-3) + (9S,12S)-12-(Benzyloxycarbonyl-methyl-amino)-16,17-dichloro-4-hydroxy-5-methoxy-10-methyl-11-oxo-2-oxa-10-aza-tricyclo[12.2.2.13,7]nonadeca-1(17),3(19),4,6,14(18),15-hexaene-9-carboxylic acid methyl ester (172036-70-3) → (9S,12S)-12-(Benzyloxycarbonyl-methyl-amino)-16,17-dichloro-4,5-dimethoxy-10-methyl-11-oxo-2-oxa-10-aza-tricyclo[12.2.2.13,7]nonadeca-1(17),3(19),4,6,14(18),15-hexaene-9-carboxylic acid methyl ester (172036-73-6)

Guidance literature:

In methanol; diethyl ether; for 1h; Ambient temperature;

DOI:10.1248/cpb.43.1325

Reference yield:

N-methyl-L-tyrosine (537-49-5) → (9S,12S)-12-(Benzyloxycarbonyl-methyl-amino)-16,17-dichloro-4,5-dimethoxy-10-methyl-11-oxo-2-oxa-10-aza-tricyclo[12.2.2.13,7]nonadeca-1(17),3(19),4,6,14(18),15-hexaene-9-carboxylic acid methyl ester (172036-73-6)

Guidance literature:

Multi-step reaction with 6 steps

1: Br₂ / methanol / Ambient temperature

2: conc. H₂SO₄ / 46 h / Heating

3: 76 percent / N,N-dicyclohexylcarbodiimide / dioxane / 20 h / Ambient temperature

4: 14.4 percent / thallium(III) trinitrate / 18 h / 4 °C

5: 56 percent / 90percent aq. AcOH, Zn / 1 h / Ambient temperature

6: 75.2 percent / diethyl ether; methanol / 1 h / Ambient temperature

With sulfuric acid; bromine; acetic acid; dicyclohexyl-carbodiimide; thallium(III) nitrate; zinc; In 1,4-dioxane; methanol; diethyl ether;

DOI:10.1248/cpb.43.1325

Reference yield:

2,6-dibromo-N-methyltyrosine methyl ester (108969-87-5) → (9S,12S)-12-(Benzyloxycarbonyl-methyl-amino)-16,17-dichloro-4,5-dimethoxy-10-methyl-11-oxo-2-oxa-10-aza-tricyclo[12.2.2.13,7]nonadeca-1(17),3(19),4,6,14(18),15-hexaene-9-carboxylic acid methyl ester (172036-73-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 76 percent / N,N-dicyclohexylcarbodiimide / dioxane / 20 h / Ambient temperature

2: 14.4 percent / thallium(III) trinitrate / 18 h / 4 °C

3: 56 percent / 90percent aq. AcOH, Zn / 1 h / Ambient temperature

4: 75.2 percent / diethyl ether; methanol / 1 h / Ambient temperature

With acetic acid; dicyclohexyl-carbodiimide; thallium(III) nitrate; zinc; In 1,4-dioxane; methanol; diethyl ether;

DOI:10.1248/cpb.43.1325

upstream raw materials:

diazomethane

(9S,12S)-12-(Benzyloxycarbonyl-methyl-amino)-16,17-dichloro-4-hydroxy-5-methoxy-10-methyl-11-oxo-2-oxa-10-aza-tricyclo[12.2.2.1^3,7]nonadeca-1⁽¹⁷⁾,3⁽¹⁹⁾,4,6,14⁽¹⁸⁾,15-hexaene-9-carboxylic acid methyl ester

N-methyl-L-tyrosine

2,6-dibromo-N-methyltyrosine methyl ester

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