Methyl 4-(N-tertbutylhydroxyamino-TBS ether) benzoate

Base Information

• Chemical Name: Methyl 4-(N-tertbutylhydroxyamino-TBS ether) benzoate
• CAS No.: 173311-82-5
• Molecular Formula: C₁₈H₃₁NO₃Si
• Molecular Weight: 337.535
• Mol file: 173311-82-5.mol

Synonyms:

Chemical Property of Methyl 4-(N-tertbutylhydroxyamino-TBS ether) benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl 4-(N-tertbutylhydroxyamino-TBS ether) benzoate

There total 4 articles about Methyl 4-(N-tertbutylhydroxyamino-TBS ether) benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1.4-dibromobenzene (106-37-6) → Methyl 4-(N-tertbutylhydroxyamino-TBS ether) benzoate (173311-82-5)

Guidance literature:

Multi-step reaction with 4 steps

1: t-BuLi / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) -78 deg C to r.t., 18 h

2: pyrazole / dimethylformamide / 22 h / 55 °C

3: t-BuLi / tetrahydrofuran / 1.) -78 deg C, 2.5 h, 2.) -78 deg C

4: K₂CO₃ / acetone / 17 h

With NH-pyrazole; tert.-butyl lithium; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;

DOI:10.1080/10587259508055274

Reference yield:

1-[N-tert-butyl-N-(hydroxylamino)]-4-bromobenzene (40686-35-9) → Methyl 4-(N-tertbutylhydroxyamino-TBS ether) benzoate (173311-82-5)

Guidance literature:

Multi-step reaction with 3 steps

1: pyrazole / dimethylformamide / 22 h / 55 °C

2: t-BuLi / tetrahydrofuran / 1.) -78 deg C, 2.5 h, 2.) -78 deg C

3: K₂CO₃ / acetone / 17 h

With NH-pyrazole; tert.-butyl lithium; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;

DOI:10.1080/10587259508055274

Reference yield:

1-[N-tert-butyl-N-(tert-butyldimethylsilyloxy)amino]-4-bromobenzene (168848-31-5) → Methyl 4-(N-tertbutylhydroxyamino-TBS ether) benzoate (173311-82-5)

Guidance literature:

Multi-step reaction with 2 steps

1: t-BuLi / tetrahydrofuran / 1.) -78 deg C, 2.5 h, 2.) -78 deg C

2: K₂CO₃ / acetone / 17 h

With tert.-butyl lithium; potassium carbonate; In tetrahydrofuran; acetone;

DOI:10.1080/10587259508055274

upstream raw materials:

1-[N-tert-butyl-N-(tert-butyldimethylsilyloxy)amino]-4-benzoic acid

methyl iodide

1.4-dibromobenzene

1-[N-tert-butyl-N-(hydroxylamino)]-4-bromobenzene