Technology Process of 2-(7-oxoheptyl)-4,5-diphenyloxazole
There total 4 articles about 2-(7-oxoheptyl)-4,5-diphenyloxazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 64 percent / pyridinium chlorochromate / Celite / CH2Cl2 / 1.5 h
2: 1.) NaI, 2.) p-toluenesulfonic acid / 1.) acetone, reflux, 36 h, 2.) benzene, reflux, 24 h
3: 1.) hexamethyl phosphoric triamide, 2.) HCl / 1.) THF, hexane, -78 degC-RT 4 h, 2.) THF, water, 60 degC-70 degC, 1 h
With
hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; toluene-4-sulfonic acid; pyridinium chlorochromate; sodium iodide;
Celite;
In
dichloromethane;
DOI:10.1016/S0040-4020(01)93281-8
- Guidance literature:
-
Multi-step reaction with 2 steps
1: LDA / tetrahydrofuran / -78 °C
2: 1.) hexamethyl phosphoric triamide, 2.) HCl / 1.) THF, hexane, -78 degC-RT 4 h, 2.) THF, water, 60 degC-70 degC, 1 h
With
hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide;
In
tetrahydrofuran;
DOI:10.1016/S0040-4020(01)93281-8
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) NaI, 2.) p-toluenesulfonic acid / 1.) acetone, reflux, 36 h, 2.) benzene, reflux, 24 h
2: 1.) hexamethyl phosphoric triamide, 2.) HCl / 1.) THF, hexane, -78 degC-RT 4 h, 2.) THF, water, 60 degC-70 degC, 1 h
With
hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; toluene-4-sulfonic acid; sodium iodide;
DOI:10.1016/S0040-4020(01)93281-8
